Protein Info for PFLU_RS27575 in Pseudomonas fluorescens SBW25

Annotation: pyrroloquinoline-quinone synthase PqqC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 TIGR02111: coenzyme PQQ biosynthesis protein C" amino acids 7 to 240 (234 residues), 418 bits, see alignment E=5.3e-130 PF03070: TENA_THI-4" amino acids 13 to 222 (210 residues), 214.4 bits, see alignment E=8.5e-68

Best Hits

Swiss-Prot: 95% identical to PQQC_PSEE4: Pyrroloquinoline-quinone synthase (pqqC) from Pseudomonas entomophila (strain L48)

KEGG orthology group: K06137, pyrroloquinoline-quinone synthase [EC: 1.3.3.11] (inferred from 100% identity to pfs:PFLU5600)

MetaCyc: 75% identical to pyrroloquinoline-quinone synthase monomer (Klebsiella pneumoniae)
Pyrroloquinoline-quinone synthase. [EC: 1.3.3.11]

Predicted SEED Role

"Pyrroloquinoline-quinone synthase (EC 1.3.3.11)" (EC 1.3.3.11)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.3.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See C3K349 at UniProt or InterPro

Protein Sequence (250 amino acids)

>PFLU_RS27575 pyrroloquinoline-quinone synthase PqqC (Pseudomonas fluorescens SBW25)
MTDTPMTPVEFEAALRAKGAFYHIHHPYHVAMYEGRATREQIQGWVANRFYYQVNIPLKD
AAILANCPDREIRREWIQRLLDHDGAPGEDGGIEAWLRLGQAVGLDPDQLRSQELVLPGV
RFAVDAYVNFARRASWQEAASSSLTELFAPQIHQSRLDSWPQHYPWIDPAGYEYFRTRLG
QARRDVEHGLTITLQHYTTREGQARMLEILQFKLDILWSMLDAMSMAYELKRPPYHSVTE
QRVWHKGIPL