Protein Info for PFLU_RS14985 in Pseudomonas fluorescens SBW25
Annotation: ornithine cyclodeaminase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01750, ornithine cyclodeaminase [EC: 4.3.1.12] (inferred from 100% identity to pfs:PFLU3072)MetaCyc: 82% identical to tyramine oxidase subunit B (Pseudomonas putida U)
Monoamine oxidase. [EC: 1.4.3.4]; 1.4.3.4 [EC: 1.4.3.4]; 1.4.3.4 [EC: 1.4.3.4]
Predicted SEED Role
"Ornithine cyclodeaminase (EC 4.3.1.12)" in subsystem Arginine and Ornithine Degradation (EC 4.3.1.12)
MetaCyc Pathways
- L-arginine degradation VII (arginase 3 pathway) (2/2 steps found)
- phenylethylamine degradation I (2/2 steps found)
- L-ornithine degradation I (L-proline biosynthesis) (1/1 steps found)
- putrescine degradation III (3/4 steps found)
- L-proline biosynthesis II (from arginine) (1/2 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (2/4 steps found)
- salidroside biosynthesis (2/4 steps found)
- serotonin degradation (4/7 steps found)
- L-tryptophan degradation VI (via tryptamine) (1/3 steps found)
- noradrenaline and adrenaline degradation (8/13 steps found)
- L-phenylalanine degradation IV (mammalian, via side chain) (5/9 steps found)
- dopamine degradation (2/5 steps found)
- phenylethanol biosynthesis (2/5 steps found)
- aromatic biogenic amine degradation (bacteria) (4/8 steps found)
- melatonin degradation II (1/4 steps found)
- superpathway of phenylethylamine degradation (6/11 steps found)
- superpathway of melatonin degradation (1/11 steps found)
KEGG Metabolic Maps
- Alkaloid biosynthesis I
- Arginine and proline metabolism
- Drug metabolism - cytochrome P450
- Glycine, serine and threonine metabolism
- Histidine metabolism
- Phenylalanine metabolism
- Tryptophan metabolism
- Tyrosine metabolism
- Urea cycle and metabolism of amino groups
Isozymes
Compare fitness of predicted isozymes for: 1.4.3.4, 4.3.1.12
Use Curated BLAST to search for 1.4.3.4 or 4.3.1.12
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See C3KB82 at UniProt or InterPro
Protein Sequence (379 amino acids)
>PFLU_RS14985 ornithine cyclodeaminase (Pseudomonas fluorescens SBW25) MSTTTKIDFIYLSEQDMIRAGVTDMLACVNTMEEMFGLLYAGDYRMAGPNNDSHGAMVIF PQESPFPNMPKPTADRRMMAMPAYLGGSFCTAGVKWYGSNIANREKGLPRSILMFTLNDP DTGAPLAHMSANLLSAYRTGAIPGVGARHLARKDSKVVGLLGPGVMGKTTLAAFIAVCPH IDTLKIKGRGQKSLDDFIAWVKHTYPQITTIEVVDTLEAVVRDSDLVTYCSSGATGDPSL YPIVRREWVKPGAFLAMPASCSLDAGMEQADVRKVLDNTGLYQAWFEELPKPAHHNVPVI GVRFMDMIAEGKMQLDDVEDIGKIIAGAAPGRRNDEEIIIMSVGGMPVEDVAWGTVVYRN AVKQGIGVTLNLWETPELR