Protein Info for PFLU_RS05980 in Pseudomonas fluorescens SBW25

Annotation: gamma-aminobutyraldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 16 to 470 (455 residues), 558.4 bits, E=5.4e-172

Best Hits

Swiss-Prot: 74% identical to ABDH_ENT38: Gamma-aminobutyraldehyde dehydrogenase (prr) from Enterobacter sp. (strain 638)

KEGG orthology group: K00137, aminobutyraldehyde dehydrogenase [EC: 1.2.1.19] (inferred from 100% identity to pfs:PFLU1209)

MetaCyc: 74% identical to gamma-aminobutyraldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.19]; 1.2.1.19 [EC: 1.2.1.19]

Predicted SEED Role

"4-aminobutyraldehyde dehydrogenase (EC 1.2.1.19)" in subsystem Polyamine Metabolism (EC 1.2.1.19)

MetaCyc Pathways

• L-lysine degradation X (5/6 steps found)
• putrescine degradation V (2/2 steps found)
• putrescine degradation IV (2/3 steps found)
• superpathway of L-arginine and L-ornithine degradation (9/13 steps found)
• putrescine degradation I (1/2 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (7/11 steps found)
• L-lysine degradation I (4/7 steps found)
• superpathway of ornithine degradation (4/8 steps found)
• superpathway of L-lysine degradation (17/43 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.19

Use Curated BLAST to search for 1.2.1.19

Sequence Analysis Tools

See C3KDS0 at UniProt or InterPro

Protein Sequence (474 amino acids)

>PFLU_RS05980 gamma-aminobutyraldehyde dehydrogenase (Pseudomonas fluorescens SBW25)
MQTKLLINGQLIEGEGPAQAVFNPALGRVLVEIKEASEAQVDAAVRAADAAFEGWSQTAP
KDRSLLLLKLADAIEAHGEELAKLESDNCGKPYSAALNDEIPAIADVFRFFAGASRCMSG
SAGGEYLPGHTSMIRRDPVGVIASIAPWNYPLMMVAWKIAPALAAGNTVVLKPSEQTPLT
ALRMVELAADIFPAGVLNLVFGRGPTVGNPLVTHPKVRMVSLTGSIATGANIISSTADSV
KRMHMELGGKAPVIIFNDADIDAAVEGIRTFGFYNAGQDCTAACRIYAQAQIYDAFVEKL
GAAVASIKYGLQDDPATELGPLITAQHRDRVAGFVERAVAQPHIRLVTGGKAVEGNGYFF
EPTVLADAQQDDEIVRREVFGPVVSVTKFTDEAQVLGWANDSDYGLASSVWTADVGRAHR
LAARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSMYGLEDYTTVRHVMFKH