Protein Info for OLJFJH_08145 in Erwinia amylovora T8

Annotation: DNA-binding response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 213 PF00072: Response_reg" amino acids 8 to 118 (111 residues), 94.4 bits, see alignment E=4.9e-31 PF00196: GerE" amino acids 151 to 206 (56 residues), 59.3 bits, see alignment E=2.2e-20

Best Hits

Swiss-Prot: 31% identical to GACA_PSEAE: Response regulator GacA (gacA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: None (inferred from 100% identity to eam:EAMY_0538)

Predicted SEED Role

"two-component response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (213 amino acids)

>OLJFJH_08145 DNA-binding response regulator (Erwinia amylovora T8)
MDKNIRLMVADDHVIMREGLKQIFSLDERLVVVAEAGNGTQVMEGLRVEPVDLLLLDMSM
PGVCGEDLVTRIHLQYPKLPILILTMYSEPQIARRVLKCGALGYITKDNDPETLLAAIHR
VARGQRFIDHVLAEQIVFAEYTQAGEAMHERLTAREMQIMLMLARGRGVNHIAEALAISN
KTVSTHKARLMEKMMFTTNADIVKYAISHCLIT