Protein Info for OLJFJH_03425 in Erwinia amylovora T8

Annotation: excinuclease ABC subunit UvrA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 942 TIGR00630: excinuclease ABC subunit A" amino acids 4 to 925 (922 residues), 1513 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 130 to 237 (108 residues), 129.5 bits, see alignment E=1.7e-41 PF17755: UvrA_DNA-bind" amino acids 290 to 399 (110 residues), 129 bits, see alignment E=3.5e-41 PF00005: ABC_tran" amino acids 786 to 861 (76 residues), 26 bits, see alignment E=4.4e-09

Best Hits

Swiss-Prot: 91% identical to UVRA_ECOLI: UvrABC system protein A (uvrA) from Escherichia coli (strain K12)

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 80% identity to aat:D11S_0457)

MetaCyc: 91% identical to UvrABC excision nuclease subunit A (Escherichia coli K-12 substr. MG1655)
3.1.25.-

Predicted SEED Role

"Excinuclease ABC subunit A" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (942 amino acids)

>OLJFJH_03425 excinuclease ABC subunit UvrA (Erwinia amylovora T8)
MDNIEVRGARTHNLKNINLIIPRDKLIVVTGLSGSGKSSLAFDTLYAEGQRRYVESLSAY
ARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTITEIHDYLRLLFARVGEPRC
PDHDVTLAAQTVSQMVDNVLSQPEGRRLMLLAPIVKDRKGEHSKTLENLASQGYIRARID
GEVCDLSDPPKLELHKKHTIEVVVDRFKVRDDLTQRLAESFETALELSGGSAVVADMDDS
SVEELLFSANFACPICGYSMNELEPRLFSFNNPAGACPTCDGLGVQQYFDPDRVVQNPEL
SLSGGAIRGWDRRNFYYFQMLRSLAEHLKFDIEAPFNSLDDRSRKVILYGSGKENIEFKY
VNDRGDTSVRRHPFEGVLHNMERRYKETESSAVREELAKYISNRSCVSCHGTRLRREARH
VFVENTTLPTISDMSIGHAMEFFQNMKLSGQRAKIAEKVLKEIGDRLKFLVNVGLNYLSM
SRSAETLSGGEAQRIRLASQIGAGLVGVMYVLDEPSIGLHQRDNERLLETLVHLRNLGNT
VIVVEHDEDAIRAADHVIDIGPGAGVHGGQVVAEGTVDDIMAVEASLTGQFLSGKRGIAI
PEQRVKGNPAKVMKLTGASGNNLKEVTLTLPVGLFTCITGVSGSGKSTLINDTLFPIAQR
QLNGATIAEAAPYRTVTGMEHFDKVIDIDQSPIGRTPRSNPATYTGIFTPVRELFAGVPE
SRTRGYTPGRFSFNVRGGRCEACQGDGVIKVEMHFLPDIYVPCDQCKGKRYNRETLEVKY
KGKNIHEVLEMTIEEAREFFDAVPALARKLQTLIDVGLSYIRLGQSATTLSGGEAQRVKL
ARELSKRGTGQTLYILDEPTTGLHFADIQQLLAVLHQLRDQGNTIVVIEHNLDVIKTADW
IVDLGPEGGSGGGEILVSGTPETVAQCERSHTARFLKPLLEQ