Protein Info for OLJFJH_02510 in Erwinia amylovora T8

Annotation: DNA mismatch repair endonuclease MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 613 TIGR00585: DNA mismatch repair protein MutL" amino acids 1 to 310 (310 residues), 343.7 bits, see alignment E=6.6e-107 PF02518: HATPase_c" amino acids 21 to 77 (57 residues), 31.7 bits, see alignment 3.5e-11 PF13589: HATPase_c_3" amino acids 24 to 120 (97 residues), 50 bits, see alignment E=6.3e-17 PF01119: DNA_mis_repair" amino acids 214 to 329 (116 residues), 129.4 bits, see alignment E=1.1e-41 PF08676: MutL_C" amino acids 437 to 568 (132 residues), 94.3 bits, see alignment E=1.1e-30

Best Hits

Swiss-Prot: 90% identical to MUTL_ERWT9: DNA mismatch repair protein MutL (mutL) from Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

KEGG orthology group: K03572, DNA mismatch repair protein MutL (inferred from 100% identity to eam:EAMY_3159)

MetaCyc: 70% identical to DNA mismatch repair protein MutL (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (613 amino acids)

>OLJFJH_02510 DNA mismatch repair endonuclease MutL (Erwinia amylovora T8)
MPIQVLPPQLANQIAAGEVVERPASVVKELVENSLDAGATRIDIDIEKGGARLIRIRDNG
CGIDKGELAMALARHATSKIASLDDLEAIISLGFRGEALASISSVSRLTLTSRTEAQSEA
WQAYAEGRDQAVTVKPAAHPVGTTLEVLDLFYNTPARRKFMRTEKTEFTHIDEIIRRIAL
ARFDVAISLSHNGKLVRQYRAVSDDGQRERRLGAICGTAFLTHALKIAWQHSELNLHGWV
ADPVGSKTLSELQYCYVNGRMMRDRLINHAIRQAYQDKLGDRHQPAYVLYLEIDPHQVDV
NVHPAKHEVRFHQSRLVHDFIYQGVVSVLQESGAETLPEIATVQPAERWQPENRQAAGGN
HFSTPATAPAAAPRPALTGGGSWQRQEPVYQKREGAVYQQLLQTPARSEEPQTAPASATQ
NKEPPLSGHTHSFGRVLTVVQQQYALLEAKNSLALLALAVAARWLKQAQLEPGSEGLKPQ
PLLIPLRLKLEKAERDAGSRCNALLNQMGIDLLFDAHHVMLRAVPLPLRQQNLQNLIPEM
LGYLARHQEVTAYQLAQWLARQSASEHQHWNHSQAITLLAEVERLCPQLVKSPPSGLLQN
VDIEMAMNALNHE