Protein Info for OKGIIK_15365 in Rhodanobacter sp. FW510-T8

Name: aroE
Annotation: shikimate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00507: shikimate dehydrogenase
  • amino acids 6 to 273 (268 residues), 224.7 bits, E=6.2e-71
• PF08501: Shikimate_dh_N
  • amino acids 8 to 90 (83 residues), 76.7 bits, E=2e-25
• PF01488: Shikimate_DH
  • amino acids 119 to 195 (77 residues), 32.9 bits, E=9.9e-12
• PF18317: SDH_C
  • amino acids 242 to 267 (26 residues), 28.7 bits, see alignment (E = 1.3e-10)

Best Hits

Swiss-Prot: 58% identical to AROE_XANC8: Shikimate dehydrogenase (NADP(+)) (aroE) from Xanthomonas campestris pv. campestris (strain 8004)

KEGG orthology group: K00014, shikimate dehydrogenase [EC: 1.1.1.25] (inferred from 58% identity to xcc:XCC3953)

Predicted SEED Role

"Shikimate 5-dehydrogenase I alpha (EC 1.1.1.25)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 1.1.1.25)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)
• superpathway of chorismate metabolism (38/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.25

Protein Sequence (276 amino acids)

>OKGIIK_15365 shikimate dehydrogenase (Rhodanobacter sp. FW510-T8)
MPAAQFAVFGHPIGHSLSPLIHQAFARQFGIDLEYRAIDAAPADFAAAVHRFFAGGGRGA
NVTLPHKAAAFALADQRSVAATRAGSANVLTPLAAGRLAAHNTDGAGLVRDITERHDLDL
RGHTALLLGAGGAAHGVAWNLLDAGVETLTIANRSPVAADVLADAIGDPLRAHTRYWEDL
ADIGSYDLIVNATSAGVLGMALQLPFSLVGARALCYDLSYGAAAGSFLAWAQAAGARYAV
DGLGMLVETAADAFELWHGRRPDTEPVFQSLRQRAA