Protein Info for OKGIIK_14900 in Rhodanobacter sp. FW510-T8

Annotation: Membrane bound FAD containing D-sorbitol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 175 transmembrane" amino acids 23 to 41 (19 residues), see Phobius details PF12318: FAD-SLDH" amino acids 20 to 174 (155 residues), 141 bits, see alignment E=2.1e-45

Best Hits

KEGG orthology group: None (inferred from 65% identity to har:HEAR2556)

Predicted SEED Role

"2-Keto-D-gluconate dehydrogenase (EC 1.1.99.4), membrane-bound, gamma subunit" in subsystem D-gluconate and ketogluconates metabolism (EC 1.1.99.4)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.1.99.4

Use Curated BLAST to search for 1.1.99.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (175 amino acids)

>OKGIIK_14900 Membrane bound FAD containing D-sorbitol dehydrogenase (Rhodanobacter sp. FW510-T8)
MAPEEPDSVAARRNGPVDPSRRRLLAGLLTAYTASLIPWALAQPAPHADRGAFTALSAIL
VGRQALDAAQATRLYDALAAAHPNFPADVQALLTLLNERHIDPQQLQGVLDGEHSPLAPL
PRQILGAWTLGVVGSGEGARCVAYETALNAVIVADVLKPPTYAYGAYGSWASKPL