Protein Info for OKGIIK_12840 in Rhodanobacter sp. FW510-T8

Annotation: Tetracycline resistance MFS efflux pump

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 transmembrane" amino acids 15 to 38 (24 residues), see Phobius details amino acids 52 to 73 (22 residues), see Phobius details amino acids 85 to 104 (20 residues), see Phobius details amino acids 110 to 131 (22 residues), see Phobius details amino acids 143 to 166 (24 residues), see Phobius details amino acids 173 to 193 (21 residues), see Phobius details amino acids 225 to 249 (25 residues), see Phobius details amino acids 261 to 280 (20 residues), see Phobius details amino acids 292 to 309 (18 residues), see Phobius details amino acids 315 to 333 (19 residues), see Phobius details amino acids 353 to 376 (24 residues), see Phobius details amino acids 383 to 404 (22 residues), see Phobius details PF12832: MFS_1_like" amino acids 12 to 165 (154 residues), 34.3 bits, see alignment E=3.6e-12 PF07690: MFS_1" amino acids 20 to 365 (346 residues), 183.7 bits, see alignment E=1.2e-57 amino acids 277 to 416 (140 residues), 37.4 bits, see alignment E=3.8e-13 PF00083: Sugar_tr" amino acids 53 to 195 (143 residues), 51 bits, see alignment E=2.8e-17 PF13347: MFS_2" amino acids 53 to 341 (289 residues), 40.8 bits, see alignment E=2.8e-14

Best Hits

KEGG orthology group: K08151, MFS transporter, DHA1 family, tetracycline resistance protein (inferred from 58% identity to xcb:XC_4243)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (450 amino acids)

>OKGIIK_12840 Tetracycline resistance MFS efflux pump (Rhodanobacter sp. FW510-T8)
MDQPSTPAEPRHRAVLAFIYVTVLLDMLAFGIIIPVLPHLIEQLAGGGIAKAAWWVGIFS
TVFAIVQFVFSPVQGALSDRYGRRPVILVSNLGLAVDFVVLALAPTLWLLFLARILLGMT
AASFSTANAYIADITPKEKRAAAFGILGSAFGLGFIIGPGLGGFLGGIALRLPFWVAAGL
ALCNFLYGCFILPESLPKERRTHRLELHSAHPFGSLKLLRRYPQVLGLAVVLFLVYLAHY
VLQTVFVLYADYRYHWGPQAVGYVLMLVGACDGAVQALLTGRLAPRFGERRVLLAGMLFG
VGAFLVMGVADTGWVFLLGVPLLALWGLAMPPIQSIMTQQVDPSEQGRLQGAISSLGSFA
GIFGPYLFAQVFALSIAPALPVHLPGVAFVLSAALMLAGMLIAARVTRSLPIAAAPRPAE
PVPAVFPGDLPPLATAHPSEPPHPPQEDHP