Protein Info for OKGIIK_11395 in Rhodanobacter sp. FW510-T8

Name: thiL
Annotation: thiamine-phosphate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01379: thiamine-phosphate kinase
  • amino acids 2 to 320 (319 residues), 352 bits, E=1.4e-109
• PF00586: AIRS
  • amino acids 25 to 135 (111 residues), 103.3 bits, E=1.1e-33
• PF02769: AIRS_C
  • amino acids 147 to 303 (157 residues), 49.4 bits, E=6.1e-17

Best Hits

KEGG orthology group: K00946, thiamine-monophosphate kinase [EC: 2.7.4.16] (inferred from 55% identity to psu:Psesu_0625)

Predicted SEED Role

"Thiamine-monophosphate kinase (EC 2.7.4.16)" in subsystem Thiamin biosynthesis (EC 2.7.4.16)

MetaCyc Pathways

• superpathway of thiamine diphosphate biosynthesis II (10/11 steps found)
• superpathway of thiamine diphosphate biosynthesis I (8/10 steps found)
• thiamine diphosphate biosynthesis I (E. coli) (2/2 steps found)
• thiamine diphosphate biosynthesis II (Bacillus) (2/2 steps found)
• thiamine diphosphate salvage II (4/5 steps found)
• thiamine diphosphate salvage V (2/3 steps found)
• thiamine diphosphate salvage I (1/2 steps found)

KEGG Metabolic Maps

• Thiamine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.4.16

Protein Sequence (321 amino acids)

>OKGIIK_11395 thiamine-phosphate kinase (Rhodanobacter sp. FW510-T8)
MEFDLIELIRRHTAQARDDVRVGIGDDAAVLAVPAGQELAVAIDTLVEGVHFPRGTTPAD
IGWKALAVNLSDLAAMGASPAWALLALTMPSADAAFVEGFAEGFAKLAQPHRLALVGGDT
TRGPLTISVAVHGFVPPGHALTRAGARAGDAVLVTGTLGDAAAGLHAVQHPPRDDDRTGL
RGFLIERLNRPTPRLAAGTALRGQATACVDVSDGLLADLGHICTASGVAAEIEAALLPRS
SALLELHDDTTALHFALSGGDDYELCFTVPAARVAELQAGLARLGCGATKIGRIVEGEGV
RVRAADGSRLATDRPGWEHFA