Protein Info for OKGIIK_09020 in Rhodanobacter sp. FW510-T8
Name: adhE
Annotation: aldehyde dehydrogenase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 57% identical to AL7A1_HUMAN: Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) from Homo sapiens
KEGG orthology group: K00128, aldehyde dehydrogenase (NAD+) [EC: 1.2.1.3] (inferred from 81% identity to psu:Psesu_1242)MetaCyc: 57% identical to Alpha-aminoadipic semialdehyde dehydrogenase (Homo sapiens)
Betaine-aldehyde dehydrogenase. [EC: 1.2.1.8]; L-aminoadipate-semialdehyde dehydrogenase. [EC: 1.2.1.8, 1.2.1.31]
Predicted SEED Role
"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)
MetaCyc Pathways
- ethanol degradation II (3/3 steps found)
- ethanol degradation IV (3/3 steps found)
- choline degradation I (2/2 steps found)
- glycine betaine biosynthesis I (Gram-negative bacteria) (2/2 steps found)
- glycine betaine biosynthesis II (Gram-positive bacteria) (2/2 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (6/8 steps found)
- phytol degradation (3/4 steps found)
- choline-O-sulfate degradation (2/3 steps found)
- ethanol degradation III (2/3 steps found)
- glycine betaine biosynthesis III (plants) (2/3 steps found)
- hypotaurine degradation (2/3 steps found)
- methylglyoxal degradation IV (2/3 steps found)
- methylglyoxal degradation V (2/3 steps found)
- L-lactaldehyde degradation (aerobic) (1/2 steps found)
- mitochondrial NADPH production (yeast) (3/5 steps found)
- choline degradation IV (2/4 steps found)
- fatty acid α-oxidation I (plants) (2/4 steps found)
- histamine degradation (1/3 steps found)
- 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
- lactate biosynthesis (archaea) (2/5 steps found)
- octane oxidation (2/5 steps found)
- superpathway of methylglyoxal degradation (4/8 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
- putrescine degradation III (1/4 steps found)
- serotonin degradation (3/7 steps found)
- L-lysine degradation XI (1/5 steps found)
- dopamine degradation (1/5 steps found)
- ceramide degradation by α-oxidation (2/7 steps found)
- limonene degradation IV (anaerobic) (2/7 steps found)
- sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
- alkane oxidation (1/6 steps found)
- L-rhamnose degradation II (2/8 steps found)
- L-lysine degradation V (2/9 steps found)
- aromatic biogenic amine degradation (bacteria) (1/8 steps found)
- noradrenaline and adrenaline degradation (4/13 steps found)
- superpathway of fucose and rhamnose degradation (3/12 steps found)
- ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)
- superpathway of L-lysine degradation (8/43 steps found)
KEGG Metabolic Maps
- 1,2-Dichloroethane degradation
- 3-Chloroacrylic acid degradation
- Arginine and proline metabolism
- Ascorbate and aldarate metabolism
- Butanoate metabolism
- Fatty acid metabolism
- Glycerolipid metabolism
- Glycine, serine and threonine metabolism
- Glycolysis / Gluconeogenesis
- Histidine metabolism
- Limonene and pinene degradation
- Lysine biosynthesis
- Lysine degradation
- Propanoate metabolism
- Pyruvate metabolism
- Tryptophan metabolism
- Urea cycle and metabolism of amino groups
- Valine, leucine and isoleucine degradation
- beta-Alanine metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.22 or 1.2.1.3 or 1.2.1.31 or 1.2.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (511 amino acids)
>OKGIIK_09020 aldehyde dehydrogenase family protein (Rhodanobacter sp. FW510-T8) MSHAILSALGLDGEQSGSYLGQGEWSKTTDAGALRPVNPATGEVIGTVHASSAADYEVIV RRAQEAFKLWRATPAPRRGEAVRLCGEALRRHKDALGSLVALEMGKIKPEGDGEVQEMID IADFAVGQSRMLYGYTMHSERPGHRMYDQYHPLGLVGIISAFNFPVAVWAWNAMLATIAG DICIWKPSPKTPLSAIATLRICNEALKAGGFPDLFFLFNDAGSDLAQAFVDDKRIPLISF TGSTKVGRMVGERVARRMGRSLLELGGNNAIILDQTADLKLAIPGIVFGAVGTAGQRCTT TRRLFVHESIFDGVLDTLVKAYGQVEGKIGDPTLATTLMGPLNSEEAVGAYLAAIEKAKA AGGTVRTGGKALTERKGNFVLPTIVTGLKNSDEVVQAETFAPILYVMPFKTIDEAIAMQN DVPQGLSSSIFTNNLKSAEQFLSAAGSDCGIANVNIGTSGAEIGGAFGGEKETGGGRESG SDAWKVYMRRQTNTINYSDALPLAQGIKFDL