Protein Info for OKGIIK_08425 in Rhodanobacter sp. FW510-T8

Name: hutI
Annotation: imidazolonepropionase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01224: imidazolonepropionase
  • amino acids 29 to 404 (376 residues), 471.1 bits, E=1.1e-145
• PF01979: Amidohydro_1
  • amino acids 66 to 392 (327 residues), 79.8 bits, E=2.4e-26
• PF07969: Amidohydro_3
  • amino acids 184 to 386 (203 residues), 60.1 bits, E=3e-20

Best Hits

Swiss-Prot: 66% identical to HUTI_RALSO: Imidazolonepropionase (hutI) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 69% identity to psu:Psesu_2247)

MetaCyc: 62% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

• L-histidine degradation II (5/5 steps found)
• L-histidine degradation VI (7/8 steps found)
• L-histidine degradation I (3/4 steps found)
• L-histidine degradation III (4/6 steps found)

KEGG Metabolic Maps

• Histidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Protein Sequence (409 amino acids)

>OKGIIK_08425 imidazolonepropionase (Rhodanobacter sp. FW510-T8)
MSETRWDRLLLNATLATFAGDAPYGLIGHGAIALHHGRIAWVGRMDALPDAPGALAATVE
SLDGALVTPGLVDCHTHLVFGGDRAHEFELRLNGASYEEIARAGGGIVSSVNATRAASEE
QLFAQSLPRAQALLADGVTTLEIKSGYGLELETERRMLRVARRLGRELGLGVRTSFLGLH
ALPPEYRDRRDDYVALVCDAMLPALAAEGLVDAVDAFCEGIGFSREETRRVFERAKQLGL
PVKLHAEQLSDLGGAALVAEYGGLSADHLEHLGESGIAAMAQAGTVAVLLPGAFYALRET
RLPPVAALREHGVPIAIATDCNPGTSPLLSLRLAAGMACTLFRLTPEEALRGITVNAARA
LGLHDRGTLAVGQRADLAMWNARQPAELCYWTGGPLVREIWIGGESAAV