Protein Info for OKGIIK_08195 in Rhodanobacter sp. FW510-T8

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 918 transmembrane" amino acids 19 to 40 (22 residues), see Phobius details amino acids 205 to 227 (23 residues), see Phobius details TIGR00229: PAS domain S-box protein" amino acids 240 to 350 (111 residues), 50.5 bits, see alignment E=2.2e-17 amino acids 358 to 472 (115 residues), 42.3 bits, see alignment E=7.4e-15 PF00989: PAS" amino acids 242 to 293 (52 residues), 27.6 bits, see alignment 8.6e-10 amino acids 357 to 461 (105 residues), 38.3 bits, see alignment E=4.2e-13 PF13188: PAS_8" amino acids 242 to 288 (47 residues), 31 bits, see alignment 6.3e-11 PF13426: PAS_9" amino acids 253 to 343 (91 residues), 24.1 bits, see alignment E=1.2e-08 amino acids 363 to 465 (103 residues), 44.1 bits, see alignment E=7.6e-15 PF08448: PAS_4" amino acids 359 to 466 (108 residues), 28.2 bits, see alignment E=6.5e-10 PF08447: PAS_3" amino acids 375 to 459 (85 residues), 27.9 bits, see alignment E=8.3e-10 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 473 to 636 (164 residues), 136.3 bits, see alignment E=8.3e-44 PF00990: GGDEF" amino acids 477 to 633 (157 residues), 135.4 bits, see alignment E=5.4e-43 PF00563: EAL" amino acids 655 to 889 (235 residues), 240 bits, see alignment E=8.4e-75

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (918 amino acids)

>OKGIIK_08195 diguanylate cyclase (Rhodanobacter sp. FW510-T8)
MHSSGNSLQKPLTRRLLPLAYALAVAIVLIMALTWGVLQVQITLAGFLNSESVWSKAQKQ
AVIDLDNYALGGDAADLVGFRDHHGLLESDRWGRDAIISGDYNKEGITRVFERGNIMPAA
QPGMTFMLQHFSGMPHVREALAAWRSTDASIAELGAIADELVAAYRAGGPSPAEIARQRG
RIKALNVYMAPRTDLFSIEVVKGAVWLGELLFWGVLGAFLIAALLWLRMARRTLEGIRGS
EERYRLLFDSAADAIVMIDETSGRILDVNRTASAWTGRSANELVGDRFVHLFMQSMAGQQ
AGRAATNVLLGADGQTRPVETQTSVANWGAQPVRQAIIRDISERVVMERERRIAAEALAS
IAEGVIIADAGRRVISTNAAHTELTGFTSQALQGRRLDDSRRLPDGKPLPQSIWDSVNAG
HAWMGEVLSIRSDGSSYPEHLSLSTIRDADGQVVHYVAVFSNIHEAKTNQLRLEHLARHD
PLTGLANRAEFERCCAEAIAVAERERLAVVVLFIDLDAFKIVNDSYSHAIGDRLLVKVAE
RIRRQLSEGDVAGRIGGDEFTVLIPRLILREDARAMVNRLLASLCEPLLVDDYEIVLSAS
IGVAGYPLDGDSALALIANADAAMYAAKTEERNAFRFYTPMMHADTRRRLQLATELRQAL
ARNEFQLVFQPSVELRTGRIVAVEALLRWRHPERGEVLPGEFIPVAESLGLIRRIDEWVM
QTTCAQIQAWDLAGVPPIRVAVNISARWFGHPAFVDGVSRTLQSRQLAPGRLLLEITESA
MLRLGDDIERTMQTLDALGIAVAIDDFGTGYSSMAYLKLPAVACLKIDRSFVTGLPGDSN
DAAITGAMLAMAKSLGLTTIAEGIETEAQHDFLLRSGCIEGQGYLYSYPLRPEEVQHLLC
PSQPPVPTRLKLVPPKRS