Protein Info for OKGIIK_07905 in Rhodanobacter sp. FW510-T8

Annotation: Diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 856 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 419 to 578 (160 residues), 155.3 bits, see alignment E=5.9e-50 PF00990: GGDEF" amino acids 420 to 576 (157 residues), 165.2 bits, see alignment E=1.1e-52 PF00563: EAL" amino acids 597 to 831 (235 residues), 251.2 bits, see alignment E=9e-79

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (856 amino acids)

>OKGIIK_07905 Diguanylate cyclase (Rhodanobacter sp. FW510-T8)
MQMNSGILVVAAQRELRRSLFDALDQAGYPQIHSARDVSHAAILLEGRPPLPPLQLMVMV
LAGDERQARISCEQLRRLPGGGDTPLILVLAEETTLGPADLPAGITDWLSAAQIGSELVP
RWRRSQAAGLRARKAVPATPDAVHDDYRYVFEEGDSEWLIVDAQSRRLLEVSPMVARHSR
MHASQWEGLALAEVLRFEGIATEQVLAEANRNWYPCQRKSAQGADTGQASVRRIRHAGSD
ALALMFRSDRADLRAEAALSLLSRIFASTSGVDAQSAAGRMLFDELGLDYLAVWSARQDG
ADAPTQMLQLWNGDDPAWPPAQMQSSLQLVLGGKPILYRTDAKRLAQVDPLLRQLDLAGF
AGLPLYDERHTVLGAMLAGSRRGFGEMGIIEPVLRCTAARFAQMLELGRTREQGRAEGLV
DALTGLPNRLLFNDRLDTIIREATRNGECFAVLFVDLDRFKAINDTHGHAAGDQVLRTVT
QRLCGSIRASDTVARYAGDEFTVVLRHIVKNDDALRVAEKIVQVMETPLYLEDGTELQVT
ASMGLSFFPDDAGDTQTLLKHADEAMYAAKHQGRNNFQIYEVSPEYALQHGMALKTRLRH
AEGNGELRVVYQPQVDTKSEDIVGMEALVRWEHPELGMISPAVFIPLAEETGLIVSIGEW
VMRTACRQAKEWEQRYGLRLRLGVNLSAVQLMEPQLLDTVARVLRETGLDPDLLEMEVTE
SISIKAVPNLVENLHGLHDLGCHIAIDDFGTGAASLDYLRRLPADRIKVDQSFVRNIGVD
PDDEAIVRATIEMAHRLKRAVVAEGVEIEQHLQFLREHGCDELQGYLFCRPLQPVSFDKL
LAERQRLLEARVAEPA