Protein Info for OKGIIK_01360 in Rhodanobacter sp. FW510-T8

Annotation: Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 965 PF13185: GAF_2" amino acids 147 to 293 (147 residues), 34.4 bits, see alignment E=6e-12 amino acids 348 to 486 (139 residues), 44.3 bits, see alignment E=5.2e-15 PF01590: GAF" amino acids 212 to 292 (81 residues), 25.3 bits, see alignment E=5e-09 amino acids 348 to 485 (138 residues), 37 bits, see alignment E=1.2e-12 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 534 to 698 (165 residues), 139.4 bits, see alignment E=4.5e-45 PF00990: GGDEF" amino acids 538 to 694 (157 residues), 169 bits, see alignment E=1.9e-53 PF00563: EAL" amino acids 716 to 950 (235 residues), 229.7 bits, see alignment E=8.4e-72

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (965 amino acids)

>OKGIIK_01360 Cyclic di-GMP metabolism protein, combines GGDEF and EAL domains with a 6TM membrane domain (Rhodanobacter sp. FW510-T8)
MSATPTIRSSPPFPVARDLAALHEAMEHLFEAADAASVMEICELMLGNFGIQGRLRWRRG
DESPGHLAGQMELAVDPQGPRTLVLDWADLPLPEPVHDRLDWMGRLAGARLRQLAETSRL
YEAISRLAQAERLQRALYAIAEQAGAEHDMPEMMRSLHAIVSSLMYAENFYIVLYDAATD
TVRFPYYIDIKDTDPPPPDQSLPLHGMLHSLTWNLLQEGRPLMGSIDELRQQFGNRLVPL
GPNCEHWLGVPLLRADHAVGGIVMQSYRDDTHYSQHDLELLNYVAQHVQTALERREAHLE
LGRRVTDRTAALREANRVLRQQVLQRQRGERLQAALFRIAELASAPESLDAFYAAVHQVI
SGLLYARNFYIAQIDEESGHLTFPYSVDDVDNVRLPRTHGRGATEYVLRHARPLLATPAE
IDRLSALGEISLFGARSVCWLGVPLIWGGKAMGVLALQSYSPEHTYNERDQELLTFVSYH
IANALQRKQAAATLKQAYAGLERRVTERTRALALANRDLREQIAERERVERRLKYETLHD
SLTGLPNRTLLLQRLEQAMQRCHANPDEQFAVLFIDLDRFKVINDSVGHLIGDDLLFQVG
GRIRACLKTRDVVARLGGDEFAVLLEGIVDANKATLIAERIISELHTPFRLGTKEIFTSA
SIGIALASPHYRQPEELLRDADAAMYHAKDGGRHRAAMFDDRLRREALSLLDMESDLRHA
LSRNEFEPFYQPIVELADGRVVGYEALLRWHHPERGLLPPHDFLLIAEECGCAEAIDWQI
FEQVCTQAVRLIGTEGFISINVSGRHFRSADLDQRLLALFDQYAVPTHCIRIEVTEHALL
ENPTQVKQMLQNLRSHGVGIALDDFGTGYSSLSYLHQYPFESLKIDRSFIIELAPDDVET
QGLALVRAIQVLADSLRMKVIAEGIEEESQRQALLRVGCRYGQGFLFAEPQPAGTWLGAG
KLLPG