Protein Info for OKGIIK_01180 in Rhodanobacter sp. FW510-T8

Name: metC
Annotation: cystathionine beta-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01053: Cys_Met_Meta_PP
  • amino acids 14 to 387 (374 residues), 507.8 bits, E=1.5e-156
• PF00155: Aminotran_1_2
  • amino acids 77 to 184 (108 residues), 25.7 bits, E=6.6e-10

Best Hits

Swiss-Prot: 64% identical to METC_COXBU: Cystathionine beta-lyase (metC) from Coxiella burnetii (strain RSA 493 / Nine Mile phase I)

KEGG orthology group: K01758, cystathionine gamma-lyase [EC: 4.4.1.1] (inferred from 73% identity to sml:Smlt0617)

MetaCyc: 53% identical to cystathionine gamma-lyase (Helicobacter pylori 26695)
Cystathionine gamma-lyase. [EC: 4.4.1.1]

Predicted SEED Role

"Cystathionine gamma-lyase (EC 4.4.1.1)" in subsystem Cysteine Biosynthesis or Glycine and Serine Utilization or Methionine Biosynthesis or Methionine Degradation (EC 4.4.1.1)

MetaCyc Pathways

• superpathway of branched chain amino acid biosynthesis (17/17 steps found)
• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• L-isoleucine biosynthesis I (from threonine) (7/7 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (12/15 steps found)
• superpathway of L-threonine metabolism (14/18 steps found)
• L-cysteine degradation II (3/3 steps found)
• L-serine degradation (3/3 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (8/10 steps found)
• L-threonine degradation I (5/6 steps found)
• L-cysteine biosynthesis III (from L-homocysteine) (2/2 steps found)
• superpathway of L-cysteine biosynthesis (mammalian) (4/5 steps found)
• homocysteine and cysteine interconversion (3/4 steps found)
• D-serine degradation (2/3 steps found)
• L-methionine degradation II (2/3 steps found)
• L-tryptophan degradation II (via pyruvate) (2/3 steps found)
• L-methionine biosynthesis II (4/6 steps found)
• hydrogen sulfide biosynthesis II (mammalian) (4/6 steps found)
• superpathway of L-cysteine biosynthesis (fungi) (4/6 steps found)
• L-cysteine biosynthesis VI (reverse transsulfuration) (4/7 steps found)
• glycine betaine degradation III (4/7 steps found)
• felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis (2/5 steps found)
• L-mimosine degradation (4/8 steps found)
• glycine betaine degradation I (4/8 steps found)
• glutathione-mediated detoxification I (3/8 steps found)
• superpathway of L-methionine salvage and degradation (8/16 steps found)
• hypoglycin biosynthesis (4/14 steps found)
• purine nucleobases degradation II (anaerobic) (9/24 steps found)

KEGG Metabolic Maps

• Cysteine metabolism
• Glycine, serine and threonine metabolism
• Methionine metabolism
• Nitrogen metabolism
• Selenoamino acid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.4.1.1

Protein Sequence (389 amino acids)

>OKGIIK_01180 cystathionine beta-lyase (Rhodanobacter sp. FW510-T8)
MKSGKQRSEQGMGTRAIHAGQHPDPSTGAIMTPIYATSTYVQESPGKHKGYEYSRTQNPT
RMAYERCVADLEGGVAGFAFASGLAAAATVLDLLDSGSHVIAMDDLYGGTYRLFERVRRR
SAGLDFSFIDLNDMAALKAALKPNTRMIWAETPTNPMLKLVDLAKVAAFAKKHGLILVVD
NTFCSPMIQRPLEFGADLVLHSATKYINGHSDMVGGIVVAGSQELAGPMGFLQNSVGAVA
GPFDAFLAMRGLKTLHLRMRQHCASALELATWLQKHPAVERVIYPGLKSHPQHALAKRQM
HGFGGIVTIEVKGGLKKARRMLERCELFALAESLGGVESLIEHPAIMTHASVPAANRKRL
GISDGLIRLSVGVEDLADLRAELTHALGS