Protein Info for OKGIIK_00155 in Rhodanobacter sp. FW510-T8

Name: hop
Annotation: ribonucleoside-diphosphate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02867: Ribonuc_red_lgC
  • amino acids 105 to 1025 (921 residues), 408.2 bits, E=5.5e-126
• PF14528: LAGLIDADG_3
  • amino acids 540 to 636 (97 residues), 79.8 bits, E=1.5e-26

Best Hits

KEGG orthology group: K00525, ribonucleoside-diphosphate reductase alpha chain [EC: 1.17.4.1] (inferred from 72% identity to aeh:Mlg_1471)

Predicted SEED Role

"Ribonucleotide reductase of class II (coenzyme B12-dependent) (EC 1.17.4.1)" in subsystem Ribonucleotide reduction (EC 1.17.4.1)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (9/9 steps found)
• superpathway of purine nucleotide salvage (12/14 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (12/14 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (8/9 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis I (5/5 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• superpathway of adenosine nucleotides de novo biosynthesis II (6/7 steps found)
• adenosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
• guanosine deoxyribonucleotides de novo biosynthesis I (2/2 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (6/8 steps found)
• adenosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)
• guanosine deoxyribonucleotides de novo biosynthesis II (3/4 steps found)

KEGG Metabolic Maps

• Glutathione metabolism
• Purine metabolism
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.4.1

Use Curated BLAST to search for 1.17.4.1

Protein Sequence (1090 amino acids)

>OKGIIK_00155 ribonucleoside-diphosphate reductase (Rhodanobacter sp. FW510-T8)
MSPAQNASMNRDAVVEIPLQPASYDIWDKKYRLKAKSGEPVDASIDETYQRVARALSDVE
ASDELRGHWYERFLWALRRGAIPAGRITSNAGALAHKPATSTINCTVSGTIHDSMDDILE
KVHEAGLTLKAGCGIGYEFSTLRPRGAYVSGAGAYTSGPLSFMDIYDKMCFTVSSAGGRR
GAQMGTFDICHPDAKEFIRAKREDGRLRQFNLSLLITDGFMEAVEHDRDWPLVFPVHVKE
QDEIDLADPSKVVWREWPTHQNYVDREDGLVACKVYGTVRARHLWDMIMVSTYDYAEPGF
ILIDKVNEMNNNWWCEHIRATNPCVTADTWVQTAEGPRQVADLLGHGFMARVDGQDHATG
AEGFFRTATKPVLALQTEEGHRLRLTEDHRVRRVSRLTRWSVDTEWCAAGALRPGDRVLL
NDHRANAQWPGALTAEQGYLLGLLVGDGTLKHEVAVLSVWPQAAVVNGSVNGGARALMAE
ALRCAQTLPHRADFAGWSEVAGRGEFRMKSAALRDLAFEFGMGVGDKAITPALEQASSEA
YRGFLRGFFDADGSVQGSQAKGVSVRLAQSDLPRLEAVQRMLLRLGVPSRIYRDRRDAGE
SRLPDGRGGTRAYATQAQHELVIAGEPLQRFAELIGFADSDKATRLKAALSGYKRTLNRA
RFVATVASLQADGVEDVYDVQVPGINTFDGNGLHAHNCGEQPLPPYGSCLLGSVNLTTFV
RDPFGPKARFDWDEYREVVKVFTRMLDNVVEINGLPLEQQRNEILGKRRHGMGFLGLGST
LTMLKMRYGSADAVSFTEDVSREMAVAGWEVALDLAKEKGAAPILLRDYTVTGDMLRKRP
EMVADGYKVGDAIPGRVLHAKYSRYMQRIATVAPNLVEQLAETGARFTHHTSIAPTGTIS
LSLANNASNGIEPSFAHSYSRNVIREGKKSKEKIEVLSFELLAYRALINADAKVSTDEPA
NRLPDYFVAADDIGPKEHVDIQAASQLWIDSSISKTANVPTDYPYEDFKDIYFYAYKQGL
KGCTTFRFNPAAFQGVLVKEADLESTLYRFELEDGSVVELKGNEQVEYDGEMHSAANLFD
ALKEGYYGKF