Protein Info for OKFHMN_25565 in Escherichia coli ECRC100

Name: hprR
Annotation: response regulator transcription factor HprR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 260 TIGR01387: heavy metal response regulator" amino acids 40 to 255 (216 residues), 380.8 bits, see alignment E=9.5e-119 PF00072: Response_reg" amino acids 40 to 149 (110 residues), 96 bits, see alignment E=1.6e-31 PF00486: Trans_reg_C" amino acids 183 to 255 (73 residues), 86.2 bits, see alignment E=1.3e-28

Best Hits

Swiss-Prot: 100% identical to HPRR_ECOLI: Transcriptional regulatory protein HprR (hprR) from Escherichia coli (strain K12)

KEGG orthology group: K02483, two-component system, OmpR family, response regulator (inferred from 98% identity to sfv:SFV_2014)

Predicted SEED Role

"Putative two-component system response regulator YedW" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (260 amino acids)

>OKFHMN_25565 response regulator transcription factor HprR (Escherichia coli ECRC100)
MSFEDSEKASRVTLQQHYNFVMNQAVSMTYDLWHIIFMKILLIEDNQRTQEWVTQGLSEA
GYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRTAKQTPVICLTARDSV
DDRVRGLDSGANDYLVKPFSFSELLARVRAQLRQHHALNSTLEISGLRMDSVSQSVSRDN
ISITLTRKEFQLLWLLASRAGEIIPRTVIASEIWGINFDSDTNTVDVAIRRLRAKVDDPF
PEKLIATIRGMGYSFVAVKK