Protein Info for OKFHMN_24705 in Escherichia coli ECRC100

Annotation: replication of DNA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 273 PF04492: Phage_rep_O" amino acids 19 to 113 (95 residues), 113 bits, see alignment E=3.8e-37 TIGR01610: phage replication protein O, N-terminal domain" amino acids 21 to 113 (93 residues), 96.8 bits, see alignment E=4.2e-32

Best Hits

Swiss-Prot: 51% identical to VG18_BPP22: DNA replication protein gp18 (18) from Salmonella phage P22

KEGG orthology group: None (inferred from 100% identity to etw:ECSP_2738)

Predicted SEED Role

"Origin specific replication initiation factor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (273 amino acids)

>OKFHMN_24705 replication of DNA (Escherichia coli ECRC100)
MGVVKLADYRPQLEVVEHRVADTEDGFMRVANEITDSLLMADLTVRQLKVMLAIMRKTYG
FNKPMDRLTNTQIAAMTGIHHTHVCAAKRQLIERKFLIADGVKIGVNKVVSQWISQDSLT
LAKTANKTLAKSANGYKPSQLNTKDNIQKTINTNTPLPPNGDGDGQVKPERRKAERIDYE
SFLNAYNTEVGDRLPHAVAVNEKRKRRLKKIIPQLKTPNVDGFRAYVRAFVHQAKPFYFG
DNDTGWTADFDYLLREDSLTGVREGKFADRGIA