Protein Info for OKFHMN_11975 in Escherichia coli ECRC101

Name: ppa
Annotation: inorganic diphosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00719: Pyrophosphatase
  • amino acids 18 to 173 (156 residues), 204.2 bits, E=4.8e-65

Best Hits

Swiss-Prot: 100% identical to IPYR_ECOLI: Inorganic pyrophosphatase (ppa) from Escherichia coli (strain K12)

KEGG orthology group: K01507, inorganic pyrophosphatase [EC: 3.6.1.1] (inferred from 100% identity to eco:b4226)

MetaCyc: 100% identical to inorganic pyrophosphatase (Escherichia coli K-12 substr. MG1655)
Triphosphatase. [EC: 3.6.1.25]; Inorganic diphosphatase. [EC: 3.6.1.25, 3.6.1.1]

Predicted SEED Role

"Inorganic pyrophosphatase (EC 3.6.1.1)" in subsystem Phosphate metabolism (EC 3.6.1.1)

MetaCyc Pathways

• (aminomethyl)phosphonate degradation (8/8 steps found)
• glyphosate degradation III (4/7 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.1 or 3.6.1.25

Protein Sequence (176 amino acids)

>OKFHMN_11975 inorganic diphosphatase (Escherichia coli ECRC101)
MSLLNVPAGKDLPEDIYVVIEIPANADPIKYEIDKESGALFVDRFMSTAMFYPCNYGYIN
HTLSLDGDPVDVLVPTPYPLQPGSVIRCRPVGVLKMTDEAGEDAKLVAVPHSKLSKEYDH
IKDVNDLPELLKAQIAHFFEHYKDLEKGKWVKVEGWENAEAAKAEIVASFERAKNK