Protein Info for OKFHMN_04530 in Escherichia coli ECRC101

Name: eAL
Annotation: EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 536 transmembrane" amino acids 12 to 28 (17 residues), see Phobius details amino acids 39 to 60 (22 residues), see Phobius details amino acids 253 to 279 (27 residues), see Phobius details PF12792: CSS-motif" amino acids 64 to 222 (159 residues), 50.4 bits, see alignment E=2e-17 PF00563: EAL" amino acids 291 to 523 (233 residues), 223.1 bits, see alignment E=3.5e-70

Best Hits

KEGG orthology group: None (inferred from 100% identity to etw:ECSP_1197)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (536 amino acids)

>OKFHMN_04530 EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant) (Escherichia coli ECRC101)
MLIIDQSAITRFYWQLYYNFLGCITLMRGETCMVFNKKMFVLIIIPGILGGLLSFAMSVF
QMNRDTTITAGILLKQLENVTQIVKHTTKLTSILVMKPCKDILEQLIANGALTPYVRTTG
LIENNFQICSSVSGFKKMNVNDVYGTSFHNKNKESRIVSISGTSFVPGKTAIVFLMPIGN
DMTAFSIVESRYIYDLMDVLDDENDDSFSLRFTEGPAIISGVNNNDRLYMLKKDFNSAIS
QASLTVTTPMISLYPYVISNVFYILPLSILLSFILYFLWQRWISRKMSLAEEIKKGMSSG
EFSVHYQPVCDTTTKACLGVEALMRWQREDGKNISPVVFIRAAEEENLIIPLTKHLFELI
IQDVQSWKVKKPFHLGINIAAEHLAHPDFVADVLHIKNAISDKFNIVLEITERNLVEDTD
HALQKINELRSHGCEFAVDDFGTGYCSLGLLQKLSVDYLKIDKSFIDTLTTAEDETPVLD
IIIKLSNRLNLITIAEGVSTSHQAEYLIHNNVTLVQGYLYAKPMKATEFYQWYVNR