Protein Info for OKFHMN_04470 in Escherichia coli ECRC100

Name: fhaC
Annotation: ShlB/FhaC/HecB family hemolysin secretion/activation protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 539 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF08479: POTRA_2" amino acids 70 to 144 (75 residues), 57.7 bits, see alignment E=1.3e-19 PF17287: POTRA_3" amino acids 158 to 195 (38 residues), 49.9 bits, see alignment 2.7e-17 PF03865: ShlB" amino acids 200 to 502 (303 residues), 228.3 bits, see alignment E=2.5e-71

Best Hits

KEGG orthology group: None (inferred from 100% identity to ece:Z1543)

Predicted SEED Role

"Channel-forming transporter/cytolysins activator of TpsB family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (539 amino acids)

>OKFHMN_04470 ShlB/FhaC/HecB family hemolysin secretion/activation protein (Escherichia coli ECRC100)
MQLRFNFGLLLILCCFQVAAKDSLDNLIKQQKNADESTLRAHKLEKKDVYSNAQRNAFTL
GDLPQEKNCFIINRIELEDNFLGGQLISEVQKAIAGRCVGSAGVQKIAAALQDYYINAGY
ITTRISIPSQDISKGKLRFQVNAGKIEKTIVEGNDISEWMLPFQRNDILNIRDIEQGLEN
LQRVPDVDVKINIEPGTRDGYSIVHIDTHRGKNWSVRASYNNWGDEETGRYQTTSVGYLF
NPAKMGDLFYLAGTRSTTGQYENVSSYYSIPVGYWEYGFFYSKSKSQQVIPLSYISLDYV
GISEYLSAKATHTVYRDKTKKFAGSAELIRRKSNYTLNGEELTLQARDMGNIKLGLNYKQ
QLPGAFWDSTLSWQRFLTWFGGEKTPDMQYGDVSPVSNIFNFEGNYTRQIENGYYNTAFF
AQYAPRELTLQDKITVGDRWSIRGFENSVGLSGNDGFYIKNTLAFPLPGMKANYYAGLDF
GQVYQDASYGDESLVGSAVGIDGNIKSLEYNFSVSTPLKYPATLDIDRVNVNFNFSYQM