Protein Info for OKFHMN_01225 in Escherichia coli ECRC101

Name: fimA
Annotation: type 1 fimbrial major subunit FimA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 883 signal peptide" amino acids 1 to 41 (41 residues), see Phobius details PF13954: PapC_N" amino acids 43 to 195 (153 residues), 155.1 bits, see alignment E=1.9e-49 PF00577: Usher" amino acids 213 to 795 (583 residues), 664.1 bits, see alignment E=3.1e-203 PF13953: PapC_C" amino acids 804 to 868 (65 residues), 75.7 bits, see alignment 3.1e-25

Best Hits

Swiss-Prot: 60% identical to FIMD_ECOLI: Outer membrane usher protein FimD (fimD) from Escherichia coli (strain K12)

KEGG orthology group: K07347, outer membrane usher protein (inferred from 100% identity to eok:G2583_1868)

Predicted SEED Role

"type 1 fimbriae anchoring protein FimD"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (883 amino acids)

>OKFHMN_01225 type 1 fimbrial major subunit FimA (Escherichia coli ECRC101)
MTAFRAAFKAYRMHQVLLLPRFARLTIALSLATAVFPVDAEYYFNPRFLSNDLAESVDLS
AFTKGREAPPGTYRVDIYLNDEFMTSRDITFITDDNNADLIPCLSTDLLVSLGIKKSALL
DNKEHSAEKHVPDNSACTPLQDRLVDASTEFDVGQQHLSLSVPQIYVGRMARGYVSPDLW
EEGINAGLLNYSFNGNSINNRSNHNAGKSNYAYLNLQSGINIGSWRLRDNSTWSYNSGSS
NSSDSNKWQHINTSAERDIIPLRSRLTVGDSYTDGDIFDSVNFRGLKINSTEAMLPDSQH
GFAPVIHGIARGTAQVSVKQNGYDVYQTTVPPGPFTIDDINSAANGGDLQVTIKEADGSI
QTLYVPYSSVPVLQRAGYTRYALAMGEYRSGNNLQSSPRFIQGSLMHGLEGNWTPYGGMQ
IAEDYQAFNLGIGKDLGLFGAFSFDITQANTTLADGTRHSGQSVKSVYSKSFYQTGTNIQ
VAGYRYSTQGFYNLSDSAYSRMSGYTVKPPTGDSNEQTQFIDYFNLFYSKRGQEQISISQ
QLGNYGATFFSASRQSYWNTSRSDQQISFGLNVPFGDITTSLNYSYSNNIWQNDRDHLLA
FTLNVPFSHWMRTDSQSAFRNSNASYSMSNDLKGGMTNLSGVYGTLLPDNNLNYSVQVGN
THGGNTSSGTSGYSTLNYRGAYGNTNVGYSRSGDSSQIYYGMSGGIIAHADGITFGQPLG
DTMVLVKAPGADNVKIENQTGIHTDWRGYAILPFATEYRENRVALNANSLADNVELDETV
VTVIPTHGAIARATFNAQIGGKVLMTLKYGNKSVPFGAIVTHGENKNGSIVAENGQVYLT
GLPQSGKLQVSWGNDKNSNCIVDYKLPEVSPGTLLNQQTAICR