Protein Info for OHPLBJKB_04371 in Escherichia coli HS(pFamp)R (ATCC 700891)

Annotation: Cyclic di-GMP phosphodiesterase PdeL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 353 PF00196: GerE" amino acids 25 to 74 (50 residues), 32 bits, see alignment 7.6e-12 PF00563: EAL" amino acids 116 to 336 (221 residues), 103.1 bits, see alignment E=1.6e-33

Best Hits

Swiss-Prot: 100% identical to YUAB_ECOLI: Uncharacterized HTH-type transcriptional regulator YuaB (yuaB) from Escherichia coli (strain K12)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (353 amino acids)

>OHPLBJKB_04371 Cyclic di-GMP phosphodiesterase PdeL (Escherichia coli HS(pFamp)R (ATCC 700891))
MNTIKIKLNLIDYDSIVNIEFPCLLSEIEIELLSQLLKGYSVNEISKRRNRSIKTVSCQK
MKLYKKLNVKSDLTLWRDVFLRFKAYLQPKNIICDNFNSSVLPVVSSKGESMAHYNIYYQ
PIYNAKNGNIAGCDVTIALKNSDGSAFALDSDRINYNPNDNKVSYLFGHINKLFSPIKNN
LPHGFFITININPEDILTCDIERECLHFIKVFGTERIRLVLQFSTKEELYIIRRYQSSLR
RIRNNNVYLSLNDFGMGYAELSHLQNIPFSYVNLHKTMFHDIESNSLTDIIATTIIDLSK
QLHIDVIADGIETKKQAGYMIERGVKYLKGIALSSPLPADAFVRKLLASLKQV