Protein Info for OHPLBJKB_04206 in Escherichia coli HS(pFamp)R (ATCC 700891)

Annotation: Xaa-Pro dipeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 PF21216: PepQ_N" amino acids 6 to 157 (152 residues), 216.4 bits, see alignment E=1.8e-68 PF00557: Peptidase_M24" amino acids 168 to 430 (263 residues), 148.8 bits, see alignment E=1.9e-47

Best Hits

Swiss-Prot: 100% identical to PEPQ_ECODH: Xaa-Pro dipeptidase (pepQ) from Escherichia coli (strain K12 / DH10B)

KEGG orthology group: K01271, Xaa-Pro dipeptidase [EC: 3.4.13.9] (inferred from 100% identity to eco:b3847)

MetaCyc: 100% identical to Xaa-Pro dipeptidase (Escherichia coli K-12 substr. MG1655)
Xaa-Pro dipeptidase. [EC: 3.4.13.9]

Predicted SEED Role

"Xaa-Pro dipeptidase PepQ (EC 3.4.13.9)" (EC 3.4.13.9)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.13.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (443 amino acids)

>OHPLBJKB_04206 Xaa-Pro dipeptidase (Escherichia coli HS(pFamp)R (ATCC 700891))
MESLASLYKNHIATLQERTRDALARFKLDALLIHSGELFNVFLDDHPYPFKVNPQFKAWV
PVTQVPNCWLLVDGVNKPKLWFYLPVDYWHNVEPLPTSFWTEDVEVIALPKADGIGSLLP
AARGNIGYIGPVPERALQLGIEASNINPKGVIDYLHYYRSFKTEYELACMREAQKMAVNG
HRAAEEAFRSGMSEFDINIAYLTATGHRDTDVPYSNIVALNEHAAVLHYTKLDHQAPEEM
RSFLLDAGAEYNGYAADLTRTWSAKSDNDYAQLVKDVNDEQLALIATMKAGVSYVDYHIQ
FHQRIAKLLRKHQIITDMSEEAMVENDLTGPFMPHGIGHPLGLQVHDVAGFMQDDSGTHL
AAPAKYPYLRCTRILQPGMVLTIEPGIYFIESLLAPWREGQFSKHFNWQKIEALKPFGGI
RIEDNVVIHENNVENMTRDLKLA