Protein Info for OHPLBJKB_03756 in Escherichia coli HS(pFamp)R (ATCC 700891)

Annotation: putative N-acetylneuraminic acid outer membrane channel protein NanC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 238 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF06178: KdgM" amino acids 22 to 236 (215 residues), 100.4 bits, see alignment E=6.1e-33

Best Hits

Swiss-Prot: 100% identical to NANC_SHIFL: Probable N-acetylneuraminic acid outer membrane channel protein NanC (nanC) from Shigella flexneri

KEGG orthology group: None (inferred from 100% identity to eco:b4311)

MetaCyc: 100% identical to N-acetylneuraminate outer membrane channel (Escherichia coli K-12 substr. MG1655)
RXN-15315; RXN0-0

Predicted SEED Role

"N-acetylneuraminic acid outer membrane channel protein NanC" in subsystem Sialic Acid Metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (238 amino acids)

>OHPLBJKB_03756 putative N-acetylneuraminic acid outer membrane channel protein NanC (Escherichia coli HS(pFamp)R (ATCC 700891))
MKKAKILSGVLLLCFSSPLISQAATLDVRGGYRSGSHAYETRLKVSEGWQNGWWASMESN
TWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGPYVKLSWDAT
KDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSKQNDY
RYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSFKL