Protein Info for OHPLBJKB_03232 in Escherichia coli HS(pFamp)R (ATCC 700891)

Annotation: Peptidyl-prolyl cis-trans isomerase D

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 623 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details PF13624: SurA_N_3" amino acids 1 to 165 (165 residues), 182.9 bits, see alignment E=1e-57 PF13623: SurA_N_2" amino acids 2 to 141 (140 residues), 121.4 bits, see alignment E=7.1e-39 PF13145: Rotamase_2" amino acids 247 to 369 (123 residues), 85.5 bits, see alignment E=1.3e-27 PF13616: Rotamase_3" amino acids 276 to 355 (80 residues), 49.7 bits, see alignment E=1.3e-16 PF00639: Rotamase" amino acids 276 to 355 (80 residues), 53 bits, see alignment E=1.5e-17

Best Hits

Swiss-Prot: 100% identical to PPID_ECOLI: Peptidyl-prolyl cis-trans isomerase D (ppiD) from Escherichia coli (strain K12)

KEGG orthology group: K03770, peptidyl-prolyl cis-trans isomerase D [EC: 5.2.1.8] (inferred from 100% identity to eco:b0441)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase PpiD (EC 5.2.1.8)" (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (623 amino acids)

>OHPLBJKB_03232 Peptidyl-prolyl cis-trans isomerase D (Escherichia coli HS(pFamp)R (ATCC 700891))
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQKISRGQFENAFN
SERNRMQQQLGDQYSELAANEGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQA
IFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQLTTQQLINGVAGTDFMLKGET
DELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDA
ATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAK
EKSADIISARNGGDMGWLEDATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAK
VKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTESLAGAEQAAGVKATQTGWFS
KDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLA
DVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPI
SQAAFALPLPAKDKPSYGMATDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIV
FEALMSNLRKEAKIKIGDALEQQ