Protein Info for OHPLBJKB_02853 in Escherichia coli HS(pFamp)R (ATCC 700891)

Annotation: DNA adenine methylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00571: DNA adenine methylase
  • amino acids 1 to 260 (260 residues), 320.8 bits, E=4.2e-100
• PF02086: MethyltransfD12
  • amino acids 7 to 244 (238 residues), 256.9 bits, E=1.2e-80

Best Hits

Swiss-Prot: 95% identical to DMA7_ECOLX: Retron EC67 DNA adenine methylase from Escherichia coli

KEGG orthology group: K06223, DNA adenine methylase [EC: 2.1.1.72] (inferred from 100% identity to ecx:EcHS_A0917)

MetaCyc: 46% identical to DNA adenine methyltransferase (Escherichia coli K-12 substr. MG1655)
Site-specific DNA-methyltransferase (adenine-specific). [EC: 2.1.1.72]

Predicted SEED Role

"Methyl-directed repair DNA adenine methylase (EC 2.1.1.72)" in subsystem DNA repair, bacterial (EC 2.1.1.72)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.72

Use Curated BLAST to search for 2.1.1.72

Protein Sequence (285 amino acids)

>OHPLBJKB_02853 DNA adenine methylase (Escherichia coli HS(pFamp)R (ATCC 700891))
MSTILKWAGNKTAIMSELKKHLPAGPRLVEPFAGSCAVMMETDYPSYLVADINPDLINLY
KKVAADCESFISRARVLFEIANREVAYYNIRQEFNYSTEITDFMKAVYFLYLNRHGYRGL
CRYNKSGHFNIPYGNYKNPYFPEKEIRAFAEKAQRATFICASFDETLAMLKAGDVVYCDP
PYDGTFSGYHTDGFTEDDQYHLASVLEHRSSEGHPVIVSNSDTSLIRSLYRNFTHHYIKV
KRSIGVAAGEGKSATEIIAVSGPRCWMGFDYSRGVDSSAVYGVRA