Protein Info for OHPLBJKB_02382 in Escherichia coli HS(pFamp)R (ATCC 700891)
Annotation: NADP/NAD-dependent aldehyde dehydrogenase PuuC
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to PUUC_ECOLI: NADP/NAD-dependent aldehyde dehydrogenase PuuC (puuC) from Escherichia coli (strain K12)
KEGG orthology group: K09472, gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [EC: 1.2.1.-] (inferred from 100% identity to eco:b1300)MetaCyc: 100% identical to gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
RXN0-3922 [EC: 1.2.1.99]; 1.2.1.99 [EC: 1.2.1.99]; Succinate-semialdehyde dehydrogenase. [EC: 1.2.1.99, 1.2.1.24]; Aminobutyraldehyde dehydrogenase. [EC: 1.2.1.99, 1.2.1.24, 1.2.1.19]
Predicted SEED Role
"Gamma-glutamyl-aminobutyraldehyde dehydrogenase (EC 1.2.1.-)" (EC 1.2.1.-)
MetaCyc Pathways
- superpathway of L-arginine and L-ornithine degradation (13/13 steps found)
- superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (11/11 steps found)
- superpathway of ornithine degradation (8/8 steps found)
- L-lysine degradation I (7/7 steps found)
- putrescine degradation II (4/4 steps found)
- superpathway of 4-aminobutanoate degradation (3/3 steps found)
- L-lysine degradation X (5/6 steps found)
- 4-aminobutanoate degradation I (2/2 steps found)
- putrescine degradation I (2/2 steps found)
- GABA shunt I (3/4 steps found)
- GABA shunt II (3/4 steps found)
- putrescine degradation IV (2/3 steps found)
- putrescine degradation V (1/2 steps found)
- 4-aminobutanoate degradation IV (1/3 steps found)
- N-methylpyrrolidone degradation (1/3 steps found)
- superpathway of L-lysine degradation (14/43 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Arginine and proline metabolism
- Butanoate metabolism
- Geraniol degradation
- Glutamate metabolism
- Limonene and pinene degradation
- Lysine biosynthesis
- Naphthalene and anthracene degradation
- Tryptophan metabolism
- Urea cycle and metabolism of amino groups
- beta-Alanine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.-, 1.2.1.19, 1.2.1.24
Use Curated BLAST to search for 1.2.1.- or 1.2.1.19 or 1.2.1.24 or 1.2.1.99
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (495 amino acids)
>OHPLBJKB_02382 NADP/NAD-dependent aldehyde dehydrogenase PuuC (Escherichia coli HS(pFamp)R (ATCC 700891)) MNFHHLAYWQDKALSLAIENRLFINGEYTAAAENETFETVDPVTQAPLAKIARGKSVDID RAMSAARGVFERGDWSLSSPAKRKAVLNKLADLMEAHAEELALLETLDTGKPIRHSLRDD IPGAARAIRWYAEAIDKVYGEVATTSSHELAMIVREPVGVIAAIVPWNFPLLLTCWKLGP ALAAGNSVILKPSEKSPLSAIRLAGLAKEAGLPDGVLNVVTGFGHEAGQALSRHNDIDAI AFTGSTRTGKQLLKDAGDSNMKRVWLEAGGKSANIVFADCPDLQQAASATAAGIFYNQGQ VCIAGTRLLLEESIADEFLALLKQQAQNWQPGHPLDPATTMGTLIDCAHADSVHSFIREG ESKGQLLLDGRNAGLAAAIGPTIFVDVDPNASLSREEIFGPVLVVTRFTSEEQALQLAND SQYGLGAAVWTRDLSRAHRMSRRLKAGSVFVNNYNDGDMTVPFGGYKQSGNGRDKSLHAL EKFTELKTIWISLEA