Protein Info for OHPLBJKB_01176 in Escherichia coli HS(pFamp)R (ATCC 700891)

Annotation: Inositol-1-monophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to SUHB_ECOL6: Inositol-1-monophosphatase (suhB) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K01092, myo-inositol-1(or 4)-monophosphatase [EC: 3.1.3.25] (inferred from 100% identity to eco:b2533)

MetaCyc: 100% identical to Nus factor SuhB (Escherichia coli K-12 substr. MG1655)
Inositol-phosphate phosphatase. [EC: 3.1.3.25]; 3.1.3.25 [EC: 3.1.3.25]; Glycerol-2-phosphatase. [EC: 3.1.3.25, 3.1.3.19]

Predicted SEED Role

"Inositol-1-monophosphatase (EC 3.1.3.25)" in subsystem Di-Inositol-Phosphate biosynthesis (EC 3.1.3.25)

MetaCyc Pathways

myo-inositol biosynthesis (1/2 steps found)
D-myo-inositol (1,4,5)-trisphosphate degradation (1/3 steps found)
superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism (1/6 steps found)
phytate degradation I (4/14 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.3.19 or 3.1.3.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (267 amino acids)

>OHPLBJKB_01176 Inositol-1-monophosphatase (Escherichia coli HS(pFamp)R (ATCC 700891))
MHPMLNIAVRAARKAGNLIAKNYETPDAVEASQKGSNDFVTNVDKAAEAVIIDTIRKSYP
QHTIITEESGELEGTDQDVQWVIDPLDGTTNFIKRLPHFAVSIAVRIKGRTEVAVVYDPM
RNELFTATRGQGAQLNGYRLRGSTARDLDGTILATGFPFKAKQYATTYINIVGKLFNECA
DFRRTGSAALDLAYVAAGRVDGFFEIGLRPWDFAAGELLVREAGGIVSDFTGGHNYMLTG
NIVAGNPRVVKAMLANMRDELSDALKR