Protein Info for OHPLBJKB_01139 in Escherichia coli HS(pFamp)R (ATCC 700891)

Annotation: Signal peptidase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 324 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 60 to 81 (22 residues), see Phobius details amino acids 94 to 103 (10 residues), see Phobius details PF10502: Peptidase_S26" amino acids 60 to 302 (243 residues), 177.7 bits, see alignment E=9.6e-57 TIGR02227: signal peptidase I" amino acids 66 to 305 (240 residues), 145 bits, see alignment E=9.2e-47

Best Hits

Swiss-Prot: 100% identical to LEP_ECOLI: Signal peptidase I (lepB) from Escherichia coli (strain K12)

KEGG orthology group: K03100, signal peptidase I [EC: 3.4.21.89] (inferred from 100% identity to eco:b2568)

MetaCyc: 100% identical to signal peptidase I (Escherichia coli K-12 substr. MG1655)
Signal peptidase I. [EC: 3.4.21.89]

Predicted SEED Role

"Signal peptidase I (EC 3.4.21.89)" in subsystem Signal peptidase (EC 3.4.21.89)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.89

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (324 amino acids)

>OHPLBJKB_01139 Signal peptidase I (Escherichia coli HS(pFamp)R (ATCC 700891))
MANMFALILVIATLVTGILWCVDKFFFAPKRRERQAAAQAAAGDSLDKATLKKVAPKPGW
LETGASVFPVLAIVLIVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTL
IETGHPKRGDIVVFKYPEDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCSSGQACENA
LPVTYSNVEPSDFVQTFSRRNGGEATSGFFEVPKNETKENGIRLSKRKETLGDVTHRILT
VPIAQDQVGMYYQQPGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAI
WMSFDKQEGEWPTGLRLSRIGGIH