Protein Info for OH686_21860 in Pseudomonas sp. S08-1

Annotation: Signal transduction histidine kinase CheA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 733 PF01627: Hpt" amino acids 9 to 101 (93 residues), 59.5 bits, see alignment E=6.4e-20 PF02895: H-kinase_dim" amino acids 339 to 397 (59 residues), 37.1 bits, see alignment 7e-13 PF02518: HATPase_c" amino acids 446 to 583 (138 residues), 67.6 bits, see alignment E=2.6e-22 PF01584: CheW" amino acids 589 to 712 (124 residues), 92.5 bits, see alignment E=3.9e-30

Best Hits

KEGG orthology group: K03407, two-component system, chemotaxis family, sensor kinase CheA [EC: 2.7.13.3] (inferred from 75% identity to pmy:Pmen_1568)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (733 amino acids)

>OH686_21860 Signal transduction histidine kinase CheA (Pseudomonas sp. S08-1)
MFDEEQWSQLLRGFIEEGRDLAKQAEEYLLVLDQAPDDQQAINGLFRAMHTLKGSAGLFT
LTPLVNFTHHLENLLMAVRDGQRQLSPPMVSLMLRCLDEISSMLELIDPDSGELPVDEAH
QGQLLDALAEQTGAPRLIATRDSDDDCASRGSLERCATCDSAGAWHISLRFHPDLLRNGF
DPASFVRYLGRLGEILHLETLAEQMPDLSEMDPESCYLGLEIALCSSASKAEIEDVFEFI
HDFCTLRILPPESALDEYIQLIQDLPETDERIGRILIASGLLTEHELAEGLSLQNDVQDG
LKSPLGSVLVETGMVPPKAVNAALAKQQSAREKAPRESSHIRVAANKLDELINLVGELVI
SAAGAQLQAQLQGSTDCIESSQTVNQHVEAIREAALKLRMIEIGDTFNRFHRVVRDVSQQ
LGKQIRLEIHGADTDLDRSVIDKLADPLTHLVRNAIDHGIESAEQRLAAGKSAEGRLSLN
AYHDSGMIVIEVEDDGRGLNTERIREKAIERGLLDPQTSLSEADTHMLIFAAGFSTADAV
SDLSGRGVGMDVVRSAIDALRGSIEIESRPGLGCTFRIRLPLTLAIIDGFLVGIGDEHFV
IPLELVTECLELDVSLDGRYGYLNLRGKPLPCIDLAAHFELPSPAHGRRNILVVSLGRQQ
AGLIVDRLHGELQTVIKPLGLLFQHLQGISGSTILGSGQIALILDIPSLLRQLQQHIESE
FRSPQPRPDLMGS