Protein Info for OH686_16335 in Pseudomonas sp. S08-1

Annotation: signal peptidase II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 169 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 69 to 88 (20 residues), see Phobius details amino acids 96 to 114 (19 residues), see Phobius details amino acids 135 to 155 (21 residues), see Phobius details TIGR00077: signal peptidase II" amino acids 10 to 162 (153 residues), 141.9 bits, see alignment E=8.6e-46 PF01252: Peptidase_A8" amino acids 15 to 158 (144 residues), 149.7 bits, see alignment E=3.4e-48

Best Hits

Swiss-Prot: 73% identical to LSPA_PSEPK: Lipoprotein signal peptidase (lspA) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K03101, signal peptidase II [EC: 3.4.23.36] (inferred from 74% identity to ppg:PputGB1_0650)

Predicted SEED Role

"Lipoprotein signal peptidase (EC 3.4.23.36)" in subsystem Sex pheromones in Enterococcus faecalis and other Firmicutes or Signal peptidase (EC 3.4.23.36)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.23.36

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (169 amino acids)

>OH686_16335 signal peptidase II (Pseudomonas sp. S08-1)
MSDASRFGRLAWLWLAVLVFVLDQGSKQIVLQVLEYGQRVTVIDGYFDWTHLYNRGAAFS
FLAAESGWQRWLFAAIAAGVSAVLVVWMKRLKSDETWLAIALAMVLGGALGNLYDRIVLG
HVVDFILVHWQDRHHFPAFNLADSGITVGAVMLALDMFKSKKSGEPAHD