Protein Info for OH686_11860 in Pseudomonas sp. S08-1

Annotation: NAD(P)H oxidoreductase YrkL or Putative NADPH-quinone reductase (modulator of drug activity B) or Flavodoxin 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 239 transmembrane" amino acids 89 to 109 (21 residues), see Phobius details amino acids 174 to 193 (20 residues), see Phobius details PF03358: FMN_red" amino acids 1 to 153 (153 residues), 35.7 bits, see alignment E=6.5e-13 PF02525: Flavodoxin_2" amino acids 1 to 208 (208 residues), 161.7 bits, see alignment E=1.9e-51

Best Hits

Swiss-Prot: 45% identical to NQO2_MOUSE: Ribosyldihydronicotinamide dehydrogenase [quinone] (Nqo2) from Mus musculus

KEGG orthology group: None (inferred from 70% identity to ppg:PputGB1_2187)

Predicted SEED Role

"NAD(P)H oxidoreductase YRKL (EC 1.6.99.-) @ Putative NADPH-quinone reductase (modulator of drug activity B) @ Flavodoxin 2" (EC 1.6.99.-)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.6.99.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (239 amino acids)

>OH686_11860 NAD(P)H oxidoreductase YrkL or Putative NADPH-quinone reductase (modulator of drug activity B) or Flavodoxin 2 (Pseudomonas sp. S08-1)
MNILIVHAHPEPQSFCTAMKDLAVATLGGAGHSVQVSDLYAMNWNPVASAADFPQRSNPD
YLVYALEQREAVKAGAIAADIAAELDKLLWADLVILNFPLFWCSVPAMLKGWIDRVLVSG
VCYGGLRFYDRGGLAGKRALLSFTLGGQAHMFADEAAVHGDWEPMLRPLQRGTLAYVGMS
VLPPFAACHVPYISQEAREEILRRYGDYLLQLEFAEPLSFPSLADFDRGLHPLQQEMTA