Protein Info for OH686_10015 in Pseudomonas sp. S08-1

Annotation: 3-dehydroquinate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01357: 3-dehydroquinate synthase
  • amino acids 40 to 377 (338 residues), 382 bits, E=1.4e-118
• PF00465: Fe-ADH
  • amino acids 42 to 208 (167 residues), 38.3 bits, E=1.1e-13
• PF13685: Fe-ADH_2
  • amino acids 44 to 212 (169 residues), 54.4 bits, E=2.5e-18
• PF01761: DHQ_synthase
  • amino acids 92 to 350 (259 residues), 356.2 bits, E=1.4e-110

Best Hits

Swiss-Prot: 80% identical to AROB_PSEPW: 3-dehydroquinate synthase (aroB) from Pseudomonas putida (strain W619)

KEGG orthology group: K01735, 3-dehydroquinate synthase [EC: 4.2.3.4] (inferred from 80% identity to ppg:PputGB1_5128)

MetaCyc: 59% identical to 3-dehydroquinate synthase (Escherichia coli K-12 substr. MG1655)
3-dehydroquinate synthase. [EC: 4.2.3.4]

Predicted SEED Role

"3-dehydroquinate synthase (EC 4.2.3.4)" in subsystem Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Type IV pilus (EC 4.2.3.4)

MetaCyc Pathways

• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• superpathway of chorismate metabolism (44/59 steps found)
• 3-dehydroquinate biosynthesis I (2/2 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.3.4

Protein Sequence (394 amino acids)

>OH686_10015 3-dehydroquinate synthase (Pseudomonas sp. S08-1)
MSVSRHCLPVKERVYLRYPMPFLFGGFMQTLTVDLGERSYPIYIGEGLLARSDLFRPHLA
GRQVAIVTNETVAPLYLDTLQQSLNGQDIASVVLPDGESFKTWETLQLIFDGLLEARHDR
KTTVIALGGGVVGDMAGFAAACYQRGVDFIQVPTTLLSQVDSSVGGKTGINHPLGKNMVG
AFYQPNAVIIDTAVLGTLPARELSAGLAEVIKYGLICDLEFLGWLEENIDALRSLQPEAL
IEAIERSCAAKAQVVGVDERESGLRAILNLGHTFGHAIETHMGYGEWLHGEAVAAGTVMA
LEMSFRLGWIATAERDRGIRLLLRAGLPVVPPAEMGPDDFLEHMAVDKKVLNGRLRLVLL
RQLGEAVITDDFPREVLDATLRADYRALLAQLGE