Protein Info for OH686_06875 in Pseudomonas sp. S08-1

Annotation: Diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 540 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 296 to 316 (21 residues), see Phobius details PF02743: dCache_1" amino acids 37 to 278 (242 residues), 48.2 bits, see alignment E=1.5e-16 PF00672: HAMP" amino acids 313 to 364 (52 residues), 33.1 bits, see alignment 8.4e-12 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 373 to 535 (163 residues), 131.3 bits, see alignment E=1.4e-42 PF00990: GGDEF" amino acids 377 to 532 (156 residues), 150.3 bits, see alignment E=6.1e-48

Best Hits

KEGG orthology group: None (inferred from 62% identity to pfv:Psefu_1156)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (540 amino acids)

>OH686_06875 Diguanylate cyclase (Pseudomonas sp. S08-1)
MRPAFSLRSHIALLIALLVTLLSWLLGTLIGNESSQRIREEVGRDLVEVSLQMIDRLDRD
MASRAAYLQVLGSLSVLRQPDDAGQIGELLDRLKREIPSIAWIGFTDPKGSVLASSGGIL
QGASLAQRPVYIQGYRGLFIGDVHEAVLLAKLLPNPSGEPMKFVDISLPVYGPDDKLAGV
LATHLSWAWADEVRRSLVEPIQQRRNVEFLILGSDHTVLLGPKAMIGQRLELHALDRPLA
EDGQWAIQRWPDGQEYVTSFAASQGYQDYAGLGWIVVARQSLDEAYAPARALSTNIVLWG
VGLALLFAAVGWLLTGYFTRPLRQIAEAADRLSVGQIAEIPDLDSPHEIAVLSQSIRHLV
ESLTHQQNALGLMENKAYSDPLTGLANRAALEKFLMLAKQREGALALLYLDLDGFKPVND
QLGHAAGDQLLKHVAIRLRGCVREGDLVARLGGDEFVLVLRVQEEEAQARIRHVAERVLH
GLQQPVRIDEQEVRIGCSIGGALWPLDNAELESVLELADQALYRAKHAGRNRAEFQKSCE