Protein Info for OH686_06735 in Pseudomonas sp. S08-1

Annotation: Transcriptional repressor of PutA and PutP / Proline dehydrogenase / Delta-1-pyrroline-5-carboxylate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1311 PF21775: PutA_1st" amino acids 11 to 43 (33 residues), 77.4 bits, see alignment (E = 1.3e-25) PF18327: PRODH" amino acids 87 to 134 (48 residues), 64.1 bits, see alignment (E = 3.4e-21) PF14850: Pro_dh-DNA_bdg" amino acids 146 to 257 (112 residues), 157.2 bits, see alignment E=6.4e-50 PF01619: Pro_dh" amino acids 267 to 567 (301 residues), 355.3 bits, see alignment E=8.3e-110 TIGR01238: delta-1-pyrroline-5-carboxylate dehydrogenase" amino acids 608 to 1108 (501 residues), 798.5 bits, see alignment E=1.1e-244 PF00171: Aldedh" amino acids 661 to 1101 (441 residues), 366.5 bits, see alignment E=5.5e-113

Best Hits

Swiss-Prot: 77% identical to PUTA_KLEAE: Bifunctional protein PutA (putA) from Klebsiella aerogenes

KEGG orthology group: K13821, proline dehydrogenase / delta 1-pyrroline-5-carboxylate dehydrogenase [EC: 1.5.1.12 1.5.99.8] (inferred from 64% identity to adk:Alide2_3117)

MetaCyc: 75% identical to trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase (Salmonella enterica enterica serovar Typhimurium)
RXN-14903 [EC: 1.5.5.2]; RXN-14116 [EC: 1.5.5.2, 1.2.1.88]

Predicted SEED Role

"Transcriptional repressor of PutA and PutP / Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)" in subsystem Arginine and Ornithine Degradation or Proline, 4-hydroxyproline uptake and utilization or Respiratory dehydrogenases 1 (EC 1.5.1.12, EC 1.5.99.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.88 or 1.5.1.12 or 1.5.5.2 or 1.5.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1311 amino acids)

>OH686_06735 Transcriptional repressor of PutA and PutP / Proline dehydrogenase  / Delta-1-pyrroline-5-carboxylate dehydrogenase  (Pseudomonas sp. S08-1)
MATTTLGVKLDDATRERLKQAAQQLDRTPHWLIKQAIFNYLEQVEGGLTPAEHSGLAAAA
GEESVDALSEQGLQVFLDFAESILPQSVLRAAITGAYRRPETEALPMLLEQARLPKEQAE
ATQKMALGIAEKLRNQKNAGGRQGLVQGLLQEFSLSSQEGVALMCLAEALLRIPDKATRD
ALIRDKIANGNWSQHLGQSPSMFVNAASWGLLITGKLVATHNEAGLSSSLNRLIGKSGEP
VIRKGVDMAMRLMGEQFVTGETIGEALANASNMESKGFRYSYDMLGEAALTEEDAKRYLA
SYEQAIHAIGKASHGRGIYEGPGISIKLSALHPRYSRAQYDRVMDELYPILLGLTKLAKQ
YDIGLNIDAEEADRLEISLDLLERLCFAPELAGWNGIGFVIQAYQKRCPYVIDYVIDLAK
RSRHRLMIRLVKGAYWDSEIKRAQVEGLEGYPVYTRKPYTDISYIACARKLLAVPEAIYP
QFATHNAHSLSAIYQIAGQNYYPGQYEFQCLHGMGEPLYEQVVGSIKDGKYNRPCRIYAP
VGSHETLLAYLVRRLLENGANTSFVNRIADHSISLKELVLDPVEQVERMAAQEGTLGLPH
PRIPLPRDLYGEARLNSEGIDLANEHRLGSLSSALLSSTNTSYVAAPMLGGDTPNPGPAE
PVRNPADHRDLVGHVHEASEADVKSAILCAQASGQIWQSTQAAERAAVLERAADQMESEI
QQLMGLLVRESGKTFANAIAEVREAVDFLRYYAAQARAFGNDSHRPLGPVVCISPWNFPL
AIFSGQVAAALAAGNTVLAKPAEQTPLIAAQAVRILLEAGVPPGAVQLLPGRGETVGARL
VGDERVRGVMFTGSTEVAGILQRNIAGRLDAQGRTVPLIAETGGLNAMIVDSSALAEQVV
IDVVSSAFDSAGQRCSALRVLCVQDDVADRVIEMLKGAMAEYRIGSPERLHTDIGPVIDA
EAKAGIEAHIAAMREKGRKVFQAARADGDEIKRGTFVLPTLIELDSFDEMKREIFGPVLH
LVRYPRAELGNLLQQINDSGYGLTLGVHTRIDETIAQVVDSAKVGNLYVNRNIVGAVVGV
QPFGGEGLSGTGPKAGGPLYLYRLLSTRPQDAVAQQLKGDNVHAIGAPAELAKARAAFAT
WAAKEEPAVAALFEQYGELSQSYTSHVLNGPTGERNTYTLLPRERVLCLADDRGDLLAQL
AATLAVGSHALLLEAQRELIGKLPKEVQKCVATVADWTSLEAEFDAILHHGDSDQLREVS
QQAAQRKGAIVSVHGLNKGETDIPLERLLIEHALSVNTAAAGGNASLMTIG