Protein Info for OH686_01005 in Pseudomonas sp. S08-1

Annotation: Multidrug efflux system, inner membrane proton/drug antiporter (RND type)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1060 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 342 to 362 (21 residues), see Phobius details amino acids 369 to 389 (21 residues), see Phobius details amino acids 396 to 419 (24 residues), see Phobius details amino acids 440 to 462 (23 residues), see Phobius details amino acids 472 to 499 (28 residues), see Phobius details amino acids 548 to 565 (18 residues), see Phobius details amino acids 879 to 901 (23 residues), see Phobius details amino acids 908 to 930 (23 residues), see Phobius details amino acids 936 to 960 (25 residues), see Phobius details amino acids 981 to 1002 (22 residues), see Phobius details amino acids 1013 to 1039 (27 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 3 to 1057 (1055 residues), 1184.7 bits, see alignment E=0 PF00873: ACR_tran" amino acids 3 to 1040 (1038 residues), 1284.5 bits, see alignment E=0 PF02355: SecD_SecF_C" amino acids 343 to 499 (157 residues), 24.6 bits, see alignment E=2.3e-09 PF03176: MMPL" amino acids 347 to 499 (153 residues), 38.7 bits, see alignment E=9.2e-14 amino acids 886 to 1050 (165 residues), 22.2 bits, see alignment E=9.3e-09

Best Hits

KEGG orthology group: None (inferred from 89% identity to avn:Avin_33870)

Predicted SEED Role

"Multidrug efflux transporter MexF"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1060 amino acids)

>OH686_01005 Multidrug efflux system, inner membrane proton/drug antiporter (RND type) (Pseudomonas sp. S08-1)
MNFSQFFIKRPIFAAVLSLLVLIAGAISLFQLPISEYPEVVPPTVVVRANFPGANPKVIG
ETVASPLEQAITGVESMLYMSSQSTADGKLTLTITFALGTDLDNAQVQVQNRVTRTMPTL
PTEVQRLGVTVDKASPDLTMVVHLTSPDQRYDMLYLSNFAALNVKDELARLDGVGDVQLF
GMGNYSLRVWLDPNKVASRNLTASDVVAAIREQNRQVAAGALGAPPSDAGNSFQLSINTQ
GRLVSEEEFENIIIRAGDDGEITRLRDIARIELGSSQYALRSLLNNQPAVAIPVFQRPGS
NAIEISDAVRARMAELKKSFPQGVDYEIVYDPTIFVRGSIEAVVHTLLEAIVLVVLVVIL
FLQTWRASIIPLAAVPVSLIGTFAVMHLFGFSLNALSLFGLVLAIGIVVDDAIVVVENVE
RNIGLGKTPIEATRQAMKEVTGPIVATALVLCAVFVPTAFISGLTGQFYQQFALTIAIST
VISAFNSLTLSPALAAVLLKDHHAPKDRFSRVLDKLFGGWLFNPFNRFFDRASHGYVGTV
KRVLRGSSIALLVYGGLLVLGYLGFSSTPTGFVPQQDKQYLVAFAQLPDAATLDRTEAVI
KRMSEIAGKHPGVENTVAFPGLSINGFTNSPNSGIVFTPLRPFDERTDPSMSAGAIAAEL
NAQFAEIQDAYIAIFPPPPVQGLGTIGGFRLQIQDRGSLGYEELYKQTQNILAKARALPE
LNPMSVFTSYQVNVPQIDANIDREKAKTHGVAISDIFDTMQVYLGSLYANDFNRFGRTYQ
VNVQAEQQFRLEPEQIGQLKVRNNRGEMIPLSTFVKVDSASGPDRVMHYNGFLTAEINGA
AAPGYSSGQAEAAIAKLLKEELPNGMTYEWTELTYQQILAGNTAIFIFPLCVLLAFLVLA
AQYESWSLPLAVILIVPTVLFSAITGVILAGGDNNVFTQIGLIVLVGLACKNAILIVEFA
KEKQEEGLDRMAAVLEACRLRLRPILMTSIAFIMGVVPLVLSSGAGAEMRHAMGVAVFSG
MIGVTFFGLLLTPVFYVLIRGFVEKREARKANQIAHEVHA