Protein Info for OH686_00930 in Pseudomonas sp. S08-1

Annotation: Multidrug efflux system MdtABC-TolC, inner-membrane proton/drug antiporter MdtC (RND type)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1035 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details transmembrane" amino acids 337 to 353 (17 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details amino acids 386 to 410 (25 residues), see Phobius details amino acids 431 to 457 (27 residues), see Phobius details amino acids 463 to 485 (23 residues), see Phobius details amino acids 529 to 547 (19 residues), see Phobius details amino acids 857 to 875 (19 residues), see Phobius details amino acids 882 to 903 (22 residues), see Phobius details amino acids 908 to 932 (25 residues), see Phobius details amino acids 954 to 974 (21 residues), see Phobius details amino acids 986 to 1012 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 6 to 1012 (1007 residues), 1047.3 bits, see alignment E=0 PF03176: MMPL" amino acids 255 to 509 (255 residues), 29.5 bits, see alignment E=5.7e-11 PF02355: SecD_SecF" amino acids 338 to 487 (150 residues), 20.6 bits, see alignment E=4e-08

Best Hits

Swiss-Prot: 57% identical to MDTC_KLEP7: Multidrug resistance protein MdtC (mdtC) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K07789, RND superfamily, multidrug transport protein MdtC (inferred from 75% identity to avn:Avin_28790)

MetaCyc: 57% identical to multidrug efflux pump RND permease subunit MdtC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-353; TRANS-RXN-92

Predicted SEED Role

"Acriflavin resistance plasma membrane protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1035 amino acids)

>OH686_00930 Multidrug efflux system MdtABC-TolC, inner-membrane proton/drug antiporter MdtC (RND type) (Pseudomonas sp. S08-1)
MNLSAPFIRRPVATLLLSLAIILAGLVSFRLLSVAPLPNMDFPAIVVKASLPGASPQTMA
SSVATPLERALGSIAGISEMTSRSSQGNTQIVILFKIGRNVDAAAREVQAAINAARNLLP
SGMRSMPTYKKFNPSQAPIMVLSLTSPQLDKSQLYDMASTVIAQKLAQVQGVGEIQIGGS
SLPAVRLQLEPRLLDQYGVALDEVRTAIAQANRDRPKGDLADADRHWQIQANDQLHKAAD
YQDLIIRYQNHAPVRLSDVAKVGDSVENRYSAGFYNEEKAVLLVVNRQPGANIIQTIEDI
RAELPALEAVMPASAKLEVAMDRSPVIRASLHEAERTLLIAVALVIMVVFLFLGRWRASL
IPALAVPVSLVGTFAVMYLLDFSLNNLSLMALIICTGLVVDDAIVVLENISRHIEAGEKP
MAAAFKGSEEVGFTLLSMNLSLVAVFLSILFMGGIVGSLFGEFAVTLTAAILISLAVSLT
LTPMLCARWLKAEEEEHEPSRLQQFGARVQERVLAFYGRSLEWALAHSRLTLFSLLLTIA
GNFYLFATVPKNLMPEQDTGQLIGFVRGDDGLSFQVMQPKMDAFRDGLLKDPAIHSVAGF
IGGESGINNAFLVVRLKPIAERDISAREVMDRLRDELPKVPGARLMLMSDQDLQFGGRQG
RSSENEYVLLASELDLLKEWTPKVRDALAALPELTDIDANEGEGAQQINLVVDRATAQRL
GVDMAMITSVLNNAFSQRQISTIYETLNQYSVVMEIDPKYAQYPEALDQIQVIGADGQRV
PLSGFARWERSLEEDRVNHQGQFAAESIGYSLAPEVTQDQANAAIRRAVAELNLPTEVQG
MLGGTGGQFEKEAQGQPVMLLIALLVVYIVLGILYESYIHPLTILSTLPSAGVGALAAIL
LTGGEFSMVSLLGLFLLIGVVKKNAILMIDLALELERNERLSPQESIRRACLLRFRPIMM
TTLAAMLGALPLLLGQAEGAEMRQPLGLAIVGGLILSQLLTLYTTPVVYLYLDRLRHRVN
RWRGMRTDAALETPL