Protein Info for OH686_00915 in Pseudomonas sp. S08-1

Annotation: Thiol peroxidase, Tpx-type

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08534: Redoxin
  • amino acids 19 to 162 (144 residues), 124.1 bits, E=4.1e-40
• PF00578: AhpC-TSA
  • amino acids 21 to 145 (125 residues), 61.1 bits, E=1.1e-20

Best Hits

Swiss-Prot: 84% identical to TPX_PSEAE: Thiol peroxidase (tpx) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K11065, thiol peroxidase, atypical 2-Cys peroxiredoxin [EC: 1.11.1.15] (inferred from 89% identity to pmy:Pmen_2432)

MetaCyc: 68% identical to lipid hydroperoxide peroxidase (Escherichia coli K-12 substr. MG1655)
1.11.1.15-RXN [EC: 1.11.1.24]

Predicted SEED Role

"Thiol peroxidase, Tpx-type (EC 1.11.1.15)" in subsystem Thioredoxin-disulfide reductase (EC 1.11.1.15)

KEGG Metabolic Maps

• Glutathione metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.11.1.15

Use Curated BLAST to search for 1.11.1.15 or 1.11.1.24

Protein Sequence (166 amino acids)

>OH686_00915 Thiol peroxidase, Tpx-type  (Pseudomonas sp. S08-1)
MAQVTLKGTPIQVDGQLPQAGQQAPAFKLVAKDLSDVSLASLAGKRKVLNIFPSVDTPTC
ATSVRKFNAEASKLANTVVLCISADLPFAQARFCGAEGLENVINLSTMRGAEFLKDYGVA
IANGPLAGVSARAVVVLDEHDKVLHSELVGEIADEPNYAAAIAALK