Protein Info for NOLOHH_24105 in Escherichia coli ECOR27

Name: pAAR
Annotation: Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1500 1612 transmembrane" amino acids 66 to 99 (34 residues), see Phobius details PF05488: PAAR_motif" amino acids 267 to 310 (44 residues), 39.1 bits, see alignment (E = 1.1e-13) PF20148: DUF6531" amino acids 393 to 451 (59 residues), 46.2 bits, see alignment (E = 7e-16) TIGR01643: YD repeat (two copies)" amino acids 553 to 592 (40 residues), 28.6 bits, see alignment (E = 1.4e-10) amino acids 618 to 649 (32 residues), 17.3 bits, see alignment (E = 5.3e-07) amino acids 666 to 699 (34 residues), 22.4 bits, see alignment (E = 1.3e-08) amino acids 679 to 720 (42 residues), 36.5 bits, see alignment (E = 4.5e-13) amino acids 725 to 761 (37 residues), 26.9 bits, see alignment (E = 4.8e-10) amino acids 764 to 802 (39 residues), 25.6 bits, see alignment (E = 1.3e-09) amino acids 869 to 909 (41 residues), 18.4 bits, see alignment (E = 2.4e-07) amino acids 976 to 1014 (39 residues), 34.4 bits, see alignment (E = 2.1e-12) amino acids 995 to 1022 (28 residues), 20.9 bits, see alignment (E = 3.8e-08) amino acids 1259 to 1290 (32 residues), 20 bits, see alignment (E = 7.5e-08) PF05593: RHS_repeat" amino acids 618 to 653 (36 residues), 27.5 bits, see alignment (E = 5.1e-10) amino acids 679 to 716 (38 residues), 34.4 bits, see alignment (E = 3.5e-12) amino acids 721 to 759 (39 residues), 34.2 bits, see alignment (E = 4e-12) amino acids 743 to 779 (37 residues), 32 bits, see alignment (E = 2e-11) amino acids 869 to 905 (37 residues), 32.2 bits, see alignment (E = 1.6e-11) amino acids 954 to 991 (38 residues), 24.8 bits, see alignment (E = 3.4e-09) amino acids 995 to 1026 (32 residues), 24.9 bits, see alignment (E = 3.3e-09) amino acids 1259 to 1288 (30 residues), 22.7 bits, see alignment (E = 1.5e-08) TIGR03696: RHS repeat-associated core domain" amino acids 1409 to 1470 (62 residues), 65.6 bits, see alignment (E = 4.7e-22)

Best Hits

KEGG orthology group: None (inferred from 98% identity to ecr:ECIAI1_0547)

Predicted SEED Role

"Rhs core protein with extension"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1612 amino acids)

>NOLOHH_24105 Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion (Escherichia coli ECOR27)
MSEGPGGPQGATAGGTLAMRMLSQQAMVASQMKRAANDKAIAQMLAAKKSGPPAARLGDE
IQHKSFLGALAGAVLGAIVTIAEGCLIMAACATGPYALVLVPALMYASYKASDYVEEKQN
QLESWINSFCDTDGAINTGSENVNINGKPAARAAVTLPPPPPPGAIPEVPQGEPSWGDIA
TDLLESAAEKAVPLAKAWGNAVITLTDSNAGFMDRLCAGTSLLFPAGPVLMEFATMVGGR
GEIKKDVDFPEAGEDTALCDKENKPPRIAQGSSNVFINNQPAARKGDKLECSAAIVEGSP
DVFIGGEQVTYLDIQPEFPPWQRMILGGITIASYLLPPAGLLGKLGNLAKLGKLGNLLGK
SGKLLGAKLGALLSRTKNALKNTYNVLKKFIKDPVDPVTGAYCDERTDFTLGQTLPLSFT
RFHCSVLPLHGLTGVGWSDSWSEYAWVREQGKRVDIISLGATLNFAFDGESDTAVNPYHA
QYILRRRDDYLELFDRDALSSRFFYDAFPGMRLRHPVTDDTSDDRLAHSPADRMYMLGGM
SDTASNRITFERDSQYRITGVSHTDGIRLKLTYHASGYLKAIHRTDNGIQTLATYEQDAR
GRLTEADARLDYHLFYEYDAADRIIRWSDNDQTWSRFTYDEQGRCVTVTGAEGYYNATLD
YGDGCTTLTDGKGTHRYYYDPDGNILREEAPDGSTTTYEWDEFHHLLARHSPAGRVEKFE
YNAAHGQLSRYTAADGAEWQYRYDERGLLSNITDPAGQTWTQQCDERGLPVSLVSPQGEE
TRLAYTAQGLLSGIFRQDERRLGIEYDHHNRPETLTDVMDREHHTEYSGHDLPVKMRGPG
GQSVRLQWQQHHKLSGIERTGTGAEGFRYDRHGNLLAWTDGNGVVWTMEYGPFDLPVART
DGEGHRWQYRYDKDTLQLTEVINPQGESYLYVLDNCGRVTEERDWGGVVWRYRYDADGLC
TARVNGLEETILYSRDAAGRLAEVITPEGKTQYAYDKSGRLTGIFSPDGTSQRTGYDERG
RVNVTTQGRRAIEYHYPDEHTVIRCILPPEDERDRHPDESLLKTTYRYNAAGELTEVILP
GDETLTFSRDEAGREVLRHSNRGFACEQGWNAAGQPVSQRAGFFPEEATWSGLVPSLVRE
YRYDSAGNVSAVTSREDYGRETRREYRLDRNGQVTAVTASGTGLGYGEGDESYGYDSCGY
LKAQSAGRHRISEETDQYAGGHRLKQAGNTQYDYDAAGRMVSRTKHRDGYRPETERFRWD
SRDQLTGYCSAQGEQWEYRHDASGRRTEKRCDRKKIRFTYLWDGDSIAEIREYRDDKLYS
VRHLVFNGFELISQQFSRVRQAHPSVAPQWVTRTNHAVSDLTGRPLMLFNSEGKTVWRPG
QTSLWGLALSLPADTGYPDPRGELDPEADPGLLYAGQWQDAESGLCYNRFRYYEPETGMY
LVSDPLGLQGGEQTYRYVPNPCGYVDPLGLATCPIIRQRVLANLEASRAARAARAASNFG
KKNIYDFIKATQSAIPGTSIPKSFEIITANGTFWVHPNATKHMAEYLTRNGLSHSTSVES
QIMLTSFHEAVSLASAQGIKYEEMMNVGGWELVFSQAKSDSALSVIKHALYK