Protein Info for NOLOHH_22795 in Escherichia coli ECOR27

Annotation: toxin-antitoxin system HicB family antitoxin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 86 PF03869: Arc" amino acids 7 to 49 (43 residues), 54.1 bits, see alignment E=1.7e-18 PF05534: HicB" amino acids 9 to 35 (27 residues), 27.2 bits, see alignment E=4.2e-10 PF11423: Repressor_Mnt" amino acids 57 to 82 (26 residues), 52.1 bits, see alignment E=6.4e-18

Best Hits

Swiss-Prot: 50% identical to RMNT_BPP22: Regulatory protein mnt (mnt) from Salmonella phage P22

KEGG orthology group: None (inferred from 90% identity to eoj:ECO26_3338)

Predicted SEED Role

"regulatory protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (86 amino acids)

>NOLOHH_22795 toxin-antitoxin system HicB family antitoxin (Escherichia coli ECOR27)
MYSKYDEAQFHLRLPHELHAKIKQRAKMNNRSLNSEIIAAIEESLDKQSSASVYIDDAER
MAEQQSDMVKKIVFDTLKELYKKDSN