Protein Info for NOLOHH_21010 in Escherichia coli ECOR27

Name: comR
Annotation: TetR family copper-responsive transcriptional repressor ComR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 231 PF00440: TetR_N" amino acids 46 to 91 (46 residues), 56.5 bits, see alignment 9.5e-20

Best Hits

Swiss-Prot: 100% identical to COMR_ECOLI: HTH-type transcriptional repressor ComR (comR) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 99% identity to ecw:EcE24377A_1233)

Predicted SEED Role

"putative transcriptional repressor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (231 amino acids)

>NOLOHH_21010 TetR family copper-responsive transcriptional repressor ComR (Escherichia coli ECOR27)
VNGGDYFYNNLSFTVTRYNGIMATDSTQCVKKSRGRPKVFDRDAALDKAMKLFWQHGYEA
TSLADLVEATGAKAPTLYAEFTNKEGLFRAVLDRYIDRFAAKHEAQLFCEEKSVESALAD
YFAAIANCFTSKDTPAGCFMINNCTTLSPDSGDIANTLKSRHAMQERTLQQFLCQRQARG
EIPTHCDVTHLAEFLNCIIQGMSISAREGASLEKLMQIAGTTLRLWPELVK