Protein Info for NOLOHH_18130 in Escherichia coli ECOR27

Name: uidB
Annotation: glucuronide transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 457 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 40 to 60 (21 residues), see Phobius details amino acids 81 to 99 (19 residues), see Phobius details amino acids 111 to 131 (21 residues), see Phobius details amino acids 149 to 170 (22 residues), see Phobius details amino acids 182 to 201 (20 residues), see Phobius details amino acids 230 to 255 (26 residues), see Phobius details amino acids 264 to 284 (21 residues), see Phobius details amino acids 296 to 315 (20 residues), see Phobius details amino acids 321 to 343 (23 residues), see Phobius details amino acids 375 to 393 (19 residues), see Phobius details amino acids 405 to 427 (23 residues), see Phobius details TIGR00792: sugar (Glycoside-Pentoside-Hexuronide) transporter" amino acids 11 to 444 (434 residues), 496.2 bits, see alignment E=3.7e-153 PF13347: MFS_2" amino acids 12 to 431 (420 residues), 303.3 bits, see alignment E=2.3e-94 PF07690: MFS_1" amino acids 23 to 378 (356 residues), 51.8 bits, see alignment E=6.3e-18

Best Hits

Swiss-Prot: 100% identical to UIDB2_ECOLI: Glucuronide carrier protein (uidB) from Escherichia coli (strain K12)

KEGG orthology group: K03292, glycoside/pentoside/hexuronide:cation symporter, GPH family (inferred from 99% identity to eco:b1616)

MetaCyc: 99% identical to glucuronide:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-98

Predicted SEED Role

"Glucuronide transporter UidB" in subsystem D-Galacturonate and D-Glucuronate Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (457 amino acids)

>NOLOHH_18130 glucuronide transporter (Escherichia coli ECOR27)
MNQQLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFA
DVFAGRVVDSVNTRWGKFRPFLLFGTAPLMIFSVLVFWVPTDWSHSSKVVYAYLTYMGLG
LCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFVCLAFLIGPSIKNSSPEEMVS
VYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPSLKISLQTLKRNRPLFMLCIGALCV
LISTFAVSASSLFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIG
ALLGTCGYLLFFWVSVWSLPVALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIE
GLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVQTPEVIMGIRTSIALVPCGFMLLA
FVIIWFYPLTDKKFKEIVVEIDNRKKVQQQLISDITN