Protein Info for NOLOHH_17140 in Escherichia coli ECOR27

Name: yeaV
Annotation: BCCT family transporter YeaV

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 536 signal peptide" amino acids 1 to 38 (38 residues), see Phobius details transmembrane" amino acids 47 to 68 (22 residues), see Phobius details amino acids 89 to 107 (19 residues), see Phobius details amino acids 137 to 159 (23 residues), see Phobius details amino acids 190 to 212 (23 residues), see Phobius details amino acids 227 to 248 (22 residues), see Phobius details amino acids 259 to 280 (22 residues), see Phobius details amino acids 315 to 332 (18 residues), see Phobius details amino acids 344 to 363 (20 residues), see Phobius details amino acids 404 to 426 (23 residues), see Phobius details amino acids 447 to 467 (21 residues), see Phobius details amino acids 473 to 493 (21 residues), see Phobius details PF02028: BCCT" amino acids 14 to 499 (486 residues), 411.6 bits, see alignment E=2.1e-127 TIGR00842: transporter, betaine/carnitine/choline transporter (BCCT) family" amino acids 55 to 499 (445 residues), 547.9 bits, see alignment E=8.8e-169

Best Hits

Swiss-Prot: 100% identical to YEAV_ECO57: Uncharacterized transporter YeaV (yeaV) from Escherichia coli O157:H7

KEGG orthology group: K03451, betaine/carnitine transporter, BCCT family (inferred from 100% identity to ecf:ECH74115_2527)

MetaCyc: 33% identical to gamma-butyrobetaine transporter (Emergencia timonensis)
TRANS-RXN-497

Predicted SEED Role

"Choline-glycine betaine transporter"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (536 amino acids)

>NOLOHH_17140 BCCT family transporter YeaV (Escherichia coli ECOR27)
MMSNVKKKDVPLISISLVAILFIAAALSLFPQQSADAANAIYTFVTRTLGSAVQVLVLLA
MGLVIYLATSKYGNIRLGEGKPEYSTLSWLFMFICAGLGSSTLYWGVAEWAYYYQTPGLN
IAPRSQQALEFSVPYSFFHWGISAWATYTLASLIMAYHFHVRKNKGLSLSGIIAAITGVR
PQGPWGKLVDLMFLIATVGALTISLVVTAATFTRGLSALTGLPDNFTVQAFVILLSGGIF
CLSSWIGINNGLQRLSKMVGWGAFLLPLLVLIVGPTEFITNSIINAIGLTTQNFLQMSLF
TDPLGDGSFTRNWTVFYWLWWISYTPGVAMFVTRVSRGRKIKEVIWGLILGSTVGCWFFF
GVMESYAIHQFINGVINVPQVLETLGGETAVQQVLMSLPAGKLFLAAYLGVMIIFLASHM
DAVAYTMAATSTRNLQEGDDPDRGLRLFWCVVITLIPLSILFTGASLETMKTTVVLTALP
FLVILLVKVGGFIRWLKQDYADIPAHQVEHYLPQTPVEALEKTPVLPAGTVFKGDN