Protein Info for NOLOHH_15070 in Escherichia coli ECOR27

Name: yieE
Annotation: DNA-binding transcriptional regulator YeiE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 268 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details PF00126: HTH_1" amino acids 2 to 39 (38 residues), 36.4 bits, see alignment 4e-13 PF03466: LysR_substrate" amino acids 61 to 261 (201 residues), 192.2 bits, see alignment E=7.4e-61

Best Hits

Swiss-Prot: 100% identical to YEIE_ECOLI: Uncharacterized HTH-type transcriptional regulator YeiE (yeiE) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to eco:b2157)

Predicted SEED Role

"LysR family transcriptional regulator YeiE" in subsystem YeiH

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (268 amino acids)

>NOLOHH_15070 DNA-binding transcriptional regulator YeiE (Escherichia coli ECOR27)
MLALSQSAVSAALTDLEGQLGVQLFDRVGKRLVVNEHGRLLYPRALALLEQAVEIEQLFR
EDNGAIRIYASSTIGNYILPAVIARYRHDYPQLPIELSVGNSQDVMQAVLDFRVDIGFIE
GPCHSTEIISEPWLEDELVVFAAPTSPLARGPVTLEQLAAAPWILRERGSGTREIVDYLL
LSHLPKFEMAMELGNSEAIKHAVRHGLGISCLSRRVIEDQLQAGTLSEVAVPLPRLMRTL
WRIHHRQKHLSNALRRFLDYCDPANVPR