Protein Info for NOLOHH_06445 in Escherichia coli ECOR27

Name: udp
Annotation: uridine phosphorylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01718: uridine phosphorylase
  • amino acids 6 to 253 (248 residues), 439.4 bits, E=1.5e-136
• PF01048: PNP_UDP_1
  • amino acids 20 to 244 (225 residues), 138.7 bits, E=1.1e-44

Best Hits

Swiss-Prot: 100% identical to UDP_ECOLI: Uridine phosphorylase (udp) from Escherichia coli (strain K12)

KEGG orthology group: K00757, uridine phosphorylase [EC: 2.4.2.3] (inferred from 100% identity to eco:b3831)

MetaCyc: 100% identical to uridine phosphorylase (Escherichia coli K-12 substr. MG1655)
Pyrimidine-nucleoside phosphorylase. [EC: 2.4.2.2, 2.4.2.3]

Predicted SEED Role

"Uridine phosphorylase (EC 2.4.2.3)" (EC 2.4.2.3)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleosides degradation (6/6 steps found)
• pyrimidine deoxyribonucleosides degradation (3/3 steps found)
• pyrimidine ribonucleosides degradation (2/2 steps found)
• superpathway of pyrimidine ribonucleosides degradation (4/5 steps found)
• nucleoside and nucleotide degradation (archaea) (4/10 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.2

Use Curated BLAST to search for 2.4.2.2 or 2.4.2.3

Protein Sequence (253 amino acids)

>NOLOHH_06445 uridine phosphorylase (Escherichia coli ECOR27)
MSKSDVFHLGLTKNDLQGATLAIVPGDPDRVEKIAALMDKPVKLASHREFTTWRAELDGK
PVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQPHINVGDVLVTTASVRLDGAS
LHFAPLEFPAVADFECTTALVEAAKSIGATTHVGVTASSDTFYPGQERYDTYSGRVVRHF
KGSMEEWQAMGVMNYEMESATLLTMCASQGLRAGMVAGVIVNRTQQEIPNAETMKQTESH
AVKIVVEAARRLL