Protein Info for NOLOHH_05490 in Escherichia coli ECOR27

Name: hupA
Annotation: DNA-binding protein HU-alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 75 90 PF00216: Bac_DNA_binding" amino acids 1 to 90 (90 residues), 117.6 bits, see alignment E=2.3e-38 PF18291: HU-HIG" amino acids 2 to 89 (88 residues), 30.9 bits, see alignment E=2.5e-11

Best Hits

Swiss-Prot: 100% identical to DBHA_ECOLW: DNA-binding protein HU-alpha (hupA) from Escherichia coli (strain ATCC 9637 / CCM 2024 / DSM 1116 / NCIMB 8666 / NRRL B-766 / W)

KEGG orthology group: K05787, DNA-binding protein HU-alpha (inferred from 100% identity to eco:b4000)

Predicted SEED Role

"DNA-binding protein HU-alpha" in subsystem DNA structural proteins, bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (90 amino acids)

>NOLOHH_05490 DNA-binding protein HU-alpha (Escherichia coli ECOR27)
MNKTQLIDVIAEKAELSKTQAKAALESTLAAITESLKEGDAVQLVGFGTFKVNHRAERTG
RNPQTGKEIKIAAANVPAFVSGKALKDAVK