Protein Info for NIAGMN_25410 in Escherichia coli ECRC102

Name: pqqL
Annotation: putative zinc protease PqqL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 927 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF00675: Peptidase_M16" amino acids 43 to 198 (156 residues), 136.6 bits, see alignment E=6.7e-44 PF05193: Peptidase_M16_C" amino acids 203 to 382 (180 residues), 101.5 bits, see alignment E=5.3e-33 amino acids 685 to 858 (174 residues), 76.1 bits, see alignment E=3.2e-25

Best Hits

Swiss-Prot: 99% identical to PQQL_ECOLI: Probable zinc protease PqqL (pqqL) from Escherichia coli (strain K12)

KEGG orthology group: K07263, zinc protease [EC: 3.4.24.-] (inferred from 100% identity to etw:ECSP_1979)

Predicted SEED Role

"Probable zinc protease pqqL (EC 3.4.99.-)" (EC 3.4.99.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-, 3.4.99.-

Use Curated BLAST to search for 3.4.24.- or 3.4.99.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (927 amino acids)

>NIAGMN_25410 putative zinc protease PqqL (Escherichia coli ECRC102)
MRNLCFLLTLVATLLLPGRLIAAALPQDEKLITGQLDNGLRYMIYPHAHPKDQVNLWLQI
HTGSLQEEDNERGVAHFVEHMMFNGTKTWPGNKVIETFESMGLRFGRDVNAYTSYDETVY
QVSLPTTQKQNLQQVMAIFSEWSNAATFEKLEVDAERGVITEEWRAHQDAKWRTSQARRP
FLLANTRNLDREPIGLMDTVATVTPAQLLQFYQRWYQPNNMTFIVVGDIDSKEALALIKD
NLSKLPANKAAENRVWPTKAENHLRFNIINDKENRVNGIALYYRLPMVQVNDEQSFIEQA
EWSMLVQLFNQRLQERIQSGELKTISGGTARSVKIAPDYQSLFFRVNARDDNMQDAANAL
MEELATIDQHGFSAEELDDVKSTRLTWLKNAVDQQAERDLRMLTSRLASSSLNNTPFLSP
EETYQLSKRLWQQITVQSLAEKWQQLRKNQDAFWEQMVNNEVAAKKALSPAAILALEKEY
ANKKLAAYIFPGRNLSLTVDADPQAEISSKETLAENLTSLTLSNGARVILAKSAGEEQKL
QIIAVSNKGDLSFPAQQKSLIALANKAVSGSGVGELSSSSLKRWSAENSVTMSSKVSGMN
TLLSVSARTNNPEPGFQLINQRITHSTINDNIWASLQNAQIQALKTLDQRPAEKFAQQMY
ETRYADDRTKLLQENQIAQFTAADALAADRQLFSSPADITFVIVGNVAEDKLVALITRYL
GSIKHSDSPLAAGKPLTRATDNASVTVKEQNEPVAQVSQWKRYDSRTPVNLATRMALDAF
NVALAKDLRVNIREQASGAYSVSSRLSVDPQAKDISHLLAFTCQPERHDELLTLANEVMV
KRLTKGISEQELNEYQQNVQRSLDIQQRSVQQLANTIVNSLIQYDDPAAWTEQEQLLKQM
TVENVNTAVKQYLSHPVNTYTGVLLPK