Protein Info for NIAGMN_23445 in Escherichia coli ECRC102

Name: stxB2a
Annotation: Shiga toxin Stx2a subunit B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 75 89 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF02258: SLT_beta" amino acids 20 to 86 (67 residues), 108.1 bits, see alignment E=9.2e-36

Best Hits

Swiss-Prot: 100% identical to STXB_BP933: Shiga-like toxin 2 subunit B (stxB2) from Enterobacteria phage 933W

KEGG orthology group: K11007, shiga toxin subunit B (inferred from 99% identity to eoi:ECO111_2429)

MetaCyc: 57% identical to Shiga toxin subunit B (Shigella dysenteriae)

Predicted SEED Role

"Shiga-like toxin II subunit B precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (89 amino acids)

>NIAGMN_23445 Shiga toxin Stx2a subunit B (Escherichia coli ECRC102)
MKKMFMAVLFALASVNAMAADCAKGKIEFSKYNEDDTFTVKVDGKEYWTSRWNLQPLLQS
AQLTGMTVTIKSSTCESGSGFAEVQFNND